Hydromorphone and Cyclobenzaprine Interaction
Drug interaction information between Hydromorphone and Cyclobenzaprine.
Hydromorphone and Cyclobenzaprine have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Hydromorphone and Cyclobenzaprine. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
This muscle relaxant and the pain medicine both impact serotonin levels, which can lead to a rare but serious reaction in the body.
FDA Label Information
Examples: Selective serotonin reuptake inhibitors (SSRIs), serotonin and norepinephrine reuptake inhibitors (SNRIs), tricyclic antidepressants (TCAs), triptans, 5-HT3 receptor antagonists, drugs that affect the serotonin neurotransmitter system (e.g., mirtazapine, trazodone, tramadol), certain muscle relaxants (i.e., cyclobenzaprine, metaxalone), monoamine oxidase (MAO) inhibitors (those intended to treat psychiatric disorders and also others, such as linezolid and intravenous methylene blue).
Hydromorphone Also Interacts With
- Trazodone minor
- Tramadol minor
- Mirtazapine minor
- Linezolid minor
- Phenelzine minor
Cyclobenzaprine Also Interacts With
- Clozapine moderate
- Tapentadol moderate
- Tranylcypromine moderate
- Acetaminophen/Oxycodone minor
- Buprenorphine minor
Frequently Asked Questions
What SPL severity band is on file for Hydromorphone + Cyclobenzaprine?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Cyclobenzaprine has 17 labeled pairs on file vs Hydromorphone's 13. In the minor band specifically: Hydromorphone has 13 (also Trazodone, Tramadol, Mirtazapine, Linezolid); Cyclobenzaprine has 14 (also Acetaminophen/Oxycodone, Buprenorphine, Buprenorphine/Naloxone, Buprenorphine).
What mechanism field is on file for Hydromorphone and Cyclobenzaprine?
This muscle relaxant and the pain medicine both impact serotonin levels, which can lead to a rare but serious reaction in the body.
Cyclobenzaprine's labeled portfolio outnumbers Hydromorphone
SPL source-record counts only. This page's band is minor · classes on file: Hydromorphone (Opioid Analgesic); Cyclobenzaprine (Muscle Relaxant).
0 major · 0 moderate · 13 minor · 13 total
- Other minor peers for Hydromorphone
- Trazodone
- Tramadol
- Mirtazapine
- Linezolid
0 major · 3 moderate · 14 minor · 17 total
- Other minor peers for Cyclobenzaprine
- Acetaminophen/Oxycodone
- Buprenorphine
- Buprenorphine/Naloxone
- Buprenorphine
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.