Hydromorphone and Linezolid Interaction
Drug interaction information between Hydromorphone and Linezolid.
Hydromorphone and Linezolid have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Hydromorphone and Linezolid. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
This antibiotic acts as an MAO inhibitor, which can cause a dangerous buildup of serotonin when used with certain pain medications.
FDA Label Information
Examples: Selective serotonin reuptake inhibitors (SSRIs), serotonin and norepinephrine reuptake inhibitors (SNRIs), tricyclic antidepressants (TCAs), triptans, 5-HT3 receptor antagonists, drugs that affect the serotonin neurotransmitter system (e.g., mirtazapine, trazodone, tramadol), certain muscle relaxants (i.e., cyclobenzaprine, metaxalone), monoamine oxidase (MAO) inhibitors (those intended to treat psychiatric disorders and also others, such as linezolid and intravenous methylene blue). Examples: Phenelzine, tranylcypromine, and linezolid.
Hydromorphone Also Interacts With
- Trazodone minor
- Tramadol minor
- Cyclobenzaprine minor
- Mirtazapine minor
- Phenelzine minor
Linezolid Also Interacts With
- Citalopram major
- Escitalopram major
- Mirtazapine major
- Paroxetine major
- Safinamide major
Frequently Asked Questions
What SPL severity band is on file for Hydromorphone + Linezolid?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Linezolid has 29 labeled pairs on file vs Hydromorphone's 13. In the minor band specifically: Hydromorphone has 13 (also Trazodone, Tramadol, Cyclobenzaprine, Mirtazapine); Linezolid has 18 (also Acetaminophen/Oxycodone, Buprenorphine, Buprenorphine/Naloxone, Buprenorphine).
What mechanism field is on file for Hydromorphone and Linezolid?
This antibiotic acts as an MAO inhibitor, which can cause a dangerous buildup of serotonin when used with certain pain medications.
Linezolid carries more major-labeled pairs than Hydromorphone
SPL source-record counts only. This page's band is minor · classes on file: Hydromorphone (Opioid Analgesic); Linezolid (Oxazolidinone Antibiotic).
Linezolid has 8 major-labeled pairs vs Hydromorphone's 0. This page itself is in the minor band, not the major band.
0 major · 0 moderate · 13 minor · 13 total
- Other minor peers for Hydromorphone
- Trazodone
- Tramadol
- Cyclobenzaprine
- Mirtazapine
8 major · 3 moderate · 18 minor · 29 total
- Other minor peers for Linezolid
- Acetaminophen/Oxycodone
- Buprenorphine
- Buprenorphine/Naloxone
- Buprenorphine
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.