Hydromorphone and Mirtazapine Interaction
Drug interaction information between Hydromorphone and Mirtazapine.
Hydromorphone and Mirtazapine have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Hydromorphone and Mirtazapine. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
These medications both change how serotonin works in your brain, which increases the risk of a severe and potentially dangerous reaction.
FDA Label Information
Examples: Selective serotonin reuptake inhibitors (SSRIs), serotonin and norepinephrine reuptake inhibitors (SNRIs), tricyclic antidepressants (TCAs), triptans, 5-HT3 receptor antagonists, drugs that affect the serotonin neurotransmitter system (e.g., mirtazapine, trazodone, tramadol), certain muscle relaxants (i.e., cyclobenzaprine, metaxalone), monoamine oxidase (MAO) inhibitors (those intended to treat psychiatric disorders and also others, such as linezolid and intravenous methylene blue).
Hydromorphone Also Interacts With
- Trazodone minor
- Tramadol minor
- Cyclobenzaprine minor
- Linezolid minor
- Phenelzine minor
Mirtazapine Also Interacts With
- Linezolid major
- Alprazolam moderate
- Diazepam moderate
- Phenelzine moderate
- Tranylcypromine moderate
Frequently Asked Questions
What SPL severity band is on file for Hydromorphone + Mirtazapine?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Mirtazapine has 29 labeled pairs on file vs Hydromorphone's 13. In the minor band specifically: Hydromorphone has 13 (also Trazodone, Tramadol, Cyclobenzaprine, Linezolid); Mirtazapine has 23 (also Buspirone, Warfarin, Carbamazepine, Lithium).
What mechanism field is on file for Hydromorphone and Mirtazapine?
These medications both change how serotonin works in your brain, which increases the risk of a severe and potentially dangerous reaction.
Mirtazapine carries more major-labeled pairs than Hydromorphone
SPL source-record counts only. This page's band is minor · classes on file: Hydromorphone (Opioid Analgesic); Mirtazapine (Noradrenergic and Specific Serotonergic Antidepressant (NaSSA)).
Mirtazapine has 1 major-labeled pair vs Hydromorphone's 0. This page itself is in the minor band, not the major band.
0 major · 0 moderate · 13 minor · 13 total
- Other minor peers for Hydromorphone
- Trazodone
- Tramadol
- Cyclobenzaprine
- Linezolid
1 major · 5 moderate · 23 minor · 29 total
- Other minor peers for Mirtazapine
- Buspirone
- Warfarin
- Carbamazepine
- Lithium
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.