What the FDA labels say about taking them together
Hydromorphone and trazodone
Hydromorphone's FDA label of May 14, 2026 names trazodone in its drug interactions section; the trazodone labels PlainMeds reads (2) do not name hydromorphone. The hydromorphone label: “The concomitant use of opioids with other drugs that affect the serotonergic neurotransmitter system has resulted in serotonin syndrome.”
Check it at the source: the hydromorphone FDA label on DailyMed (effective May 14, 2026, Rhodes Pharmaceuticals LLC); the trazodone FDA label on DailyMed (effective January 22, 2026, Zydus Pharmaceuticals USA Inc.).
What does the hydromorphone label say about trazodone?
Hydromorphone label, drug interactionsSerotonergic Drugs Clinical Impact: The concomitant use of opioids with other drugs that affect the serotonergic neurotransmitter system has resulted in serotonin syndrome. … 5-HT3 receptor antagonists, drugs that affect the serotonin neurotransmitter system (e.g., mirtazapine, trazodone, tramadol), certain muscle relaxants (i.e., cyclobenzaprine, metaxalone), monoamine oxidase (MAO) inhibitors (those intended to treat psychiatric disorders and also others, such as linezolid and …
Source: FDA drug label (Hydromorphone Hydrochloride, NDA019034), Fresenius Kabi USA, LLC, effective July 15, 2026 (SPL set e034eb96-03e0-46e1-8b92-5e1f94555e7b), via openFDA
Source: FDA drug label (Hydromorphone Hydrochloride), Rhodes Pharmaceuticals LLC, effective May 14, 2026 (SPL set 37565441-0d95-4743-a695-d7b3326f58a1), via openFDA; the full label on DailyMed
What does the trazodone label say about hydromorphone?
Trazodone's label (effective January 22, 2026) and its 1 other brand-application label do not name hydromorphone in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Trazodone Hydrochloride), Zydus Pharmaceuticals USA Inc., effective January 22, 2026 (SPL set 704aebf9-2fff-4ef3-8323-9ff0d7f0ffd9), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Hydromorphone | Trazodone | |
|---|---|---|
| Labeled for | Pain | Depression |
| Boxed warning | Yes | Yes |
| Pharmacy cost (NADAC) | $0.219 per tablet 4 mg tablet | $0.0307 per tablet 50 mg tablet |
| Shortage now | In shortage | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once