Glucagon and Insulin Degludec Interaction
Drug interaction information between Glucagon and Insulin Degludec.
Glucagon and Insulin Degludec have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Glucagon and Insulin Degludec. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Glucagon naturally raises blood sugar, which works against the way insulin lowers it.
FDA Label Information
Drugs That May Decrease the Blood Glucose Lowering Effect of XULTOPHY 100/3.6 Drugs: Atypical antipsychotics (e.g., olanzapine and clozapine), corticosteroids, danazol, diuretics, estrogens, glucagon, isoniazid, niacin, oral contraceptives, phenothiazines, progestogens (e.g., in oral contraceptives), protease inhibitors, somatropin, sympathomimetic agents (e.g., albuterol, epinephrine, terbutaline), and thyroid hormones.
Glucagon Also Interacts With
- Warfarin minor
- Indomethacin minor
- Glimepiride minor
- Insulin Aspart minor
- Insulin Detemir minor
Insulin Degludec Also Interacts With
- Fluoxetine moderate
- Liraglutide moderate
- Pramlintide moderate
- Octreotide moderate
- Albuterol minor
Frequently Asked Questions
What SPL severity band is on file for Glucagon + Insulin Degludec?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Glucagon has 14 labeled pairs on file vs Insulin Degludec's 12. In the minor band specifically: Glucagon has 14 (also Warfarin, Indomethacin, Glimepiride, Insulin Aspart); Insulin Degludec has 8 (also Albuterol, Clonidine, Olanzapine, Lithium).
What mechanism field is on file for Glucagon and Insulin Degludec?
Glucagon naturally raises blood sugar, which works against the way insulin lowers it.
Glucagon's labeled portfolio outnumbers Insulin Degludec
SPL source-record counts only. This page's band is minor · classes on file: Glucagon (Glucagon (Hypoglycemia Rescue)); Insulin Degludec (Ultra-Long-Acting Insulin).
0 major · 0 moderate · 14 minor · 14 total
- Other minor peers for Glucagon
- Warfarin
- Indomethacin
- Glimepiride
- Insulin Aspart
0 major · 4 moderate · 8 minor · 12 total
- Other minor peers for Insulin Degludec
- Albuterol
- Clonidine
- Olanzapine
- Lithium
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.