Insulin Degludec and Pramlintide Interaction
Drug interaction information between Insulin Degludec and Pramlintide.
Insulin Degludec and Pramlintide have a documented moderate interaction in FDA labeling.
FDA drug labeling documents a moderate-severity interaction between Insulin Degludec and Pramlintide. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Both drugs work to lower blood sugar, so taking them at the same time can cause your blood sugar to drop too low.
FDA Label Information
Drugs That May Increase the Risk of Hypoglycemia Drugs: Antidiabetic agents, ACE inhibitors, angiotensin II receptor blocking agents, disopyramide, fibrates, fluoxetine, monoamine oxidase inhibitors, pentoxifylline, pramlintide, salicylates, somatostatin analogs (e.g., octreotide), and sulfonamide antibiotics Intervention: Dosage reductions and increased frequency of glucose monitoring may be required when XULTOPHY 100/3.6 is coadministered with these drugs.
Insulin Degludec Also Interacts With
- Fluoxetine moderate
- Liraglutide moderate
- Octreotide moderate
- Albuterol minor
- Clonidine minor
Pramlintide Also Interacts With
- Insulin Aspart moderate
- Insulin Detemir moderate
- Insulin Glargine moderate
- Insulin Glulisine moderate
- Insulin Human/Insulin Isophane moderate
Frequently Asked Questions
What SPL severity band is on file for Insulin Degludec + Pramlintide?
Compiled FDA labeling labels this pair moderate. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Pramlintide has 13 labeled pairs on file vs Insulin Degludec's 12. In the moderate band specifically: Insulin Degludec has 4 (also Fluoxetine, Liraglutide, Octreotide); Pramlintide has 9 (also Insulin Aspart, Insulin Detemir, Insulin Glargine, Insulin Glulisine).
What mechanism field is on file for Insulin Degludec and Pramlintide?
Both drugs work to lower blood sugar, so taking them at the same time can cause your blood sugar to drop too low.
Pramlintide's labeled portfolio outnumbers Insulin Degludec
SPL source-record counts only. This page's band is moderate · classes on file: Insulin Degludec (Ultra-Long-Acting Insulin); Pramlintide (Amylin Analog).
0 major · 4 moderate · 8 minor · 12 total
- Other moderate peers for Insulin Degludec
- Fluoxetine
- Liraglutide
- Octreotide
0 major · 9 moderate · 4 minor · 13 total
- Other moderate peers for Pramlintide
- Insulin Aspart
- Insulin Detemir
- Insulin Glargine
- Insulin Glulisine
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.