Glucagon and Glimepiride Interaction
Drug interaction information between Glucagon and Glimepiride.
Glucagon and Glimepiride have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Glucagon and Glimepiride. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Glucagon is used to raise blood sugar, so it works against glimepiride's ability to lower it.
FDA Label Information
The following are examples of medications that may reduce the glucose-lowering effect of sulfonylureas including glimepiride, leading to worsening glycemic control: danazol, glucagon, somatropin, protease inhibitors, atypical antipsychotic medications (e.g., olanzapine and clozapine), barbiturates, diazoxide, laxatives, rifampin, thiazides and other diuretics, corticosteroids, phenothiazines, thyroid hormones, estrogens, oral contraceptives, phenytoin, nicotinic acid, sympathomimetics (e.g., epinephrine, albuterol, terbutaline), and isoniazid.
Glucagon Also Interacts With
- Warfarin minor
- Indomethacin minor
- Insulin Aspart minor
- Insulin Degludec minor
- Insulin Detemir minor
Glimepiride Also Interacts With
- Albuterol minor
- Fluoxetine minor
- Clonidine minor
- Olanzapine minor
- Fluconazole minor
Frequently Asked Questions
What SPL severity band is on file for Glucagon + Glimepiride?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Glimepiride has 16 labeled pairs on file vs Glucagon's 14. In the minor band specifically: Glucagon has 14 (also Warfarin, Indomethacin, Insulin Aspart, Insulin Degludec); Glimepiride has 16 (also Albuterol, Fluoxetine, Clonidine, Olanzapine).
What mechanism field is on file for Glucagon and Glimepiride?
Glucagon is used to raise blood sugar, so it works against glimepiride's ability to lower it.
Glimepiride's labeled portfolio outnumbers Glucagon
SPL source-record counts only. This page's band is minor · classes on file: Glucagon (Glucagon (Hypoglycemia Rescue)); Glimepiride (Sulfonylurea).
0 major · 0 moderate · 14 minor · 14 total
- Other minor peers for Glucagon
- Warfarin
- Indomethacin
- Insulin Aspart
- Insulin Degludec
0 major · 0 moderate · 16 minor · 16 total
- Other minor peers for Glimepiride
- Albuterol
- Fluoxetine
- Clonidine
- Olanzapine
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.