Glucagon and Insulin Aspart Interaction
Drug interaction information between Glucagon and Insulin Aspart.
Glucagon and Insulin Aspart have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Glucagon and Insulin Aspart. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Glucagon acts to raise blood sugar, which directly opposes the way insulin works to lower it. This makes the insulin less effective at controlling your sugar levels.
FDA Label Information
Drugs That May Decrease the Blood Glucose Lowering Effect of NOVOLOG Drugs: Atypical antipsychotics (e.g., olanzapine and clozapine), corticosteroids, danazol, diuretics, estrogens, glucagon, isoniazid, niacin, oral contraceptives, phenothiazines, progestogens (e.g., in oral contraceptives), protease inhibitors, somatropin, sympathomimetic agents (e.g., albuterol, epinephrine, terbutaline), and thyroid hormones. • Drugs that may decrease the blood glucose lowering effect: atypical antipsychotics, corticosteroids, danazol, diuretics, estrogens, glucagon, isoniazid, niacin, oral...
Glucagon Also Interacts With
- Warfarin minor
- Indomethacin minor
- Glimepiride minor
- Insulin Degludec minor
- Insulin Detemir minor
Insulin Aspart Also Interacts With
- Fluoxetine moderate
- Pramlintide moderate
- Octreotide moderate
- Albuterol minor
- Clonidine minor
Frequently Asked Questions
What SPL severity band is on file for Glucagon + Insulin Aspart?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Glucagon has 14 labeled pairs on file vs Insulin Aspart's 11. In the minor band specifically: Glucagon has 14 (also Warfarin, Indomethacin, Glimepiride, Insulin Degludec); Insulin Aspart has 8 (also Albuterol, Clonidine, Olanzapine, Lithium).
What mechanism field is on file for Glucagon and Insulin Aspart?
Glucagon acts to raise blood sugar, which directly opposes the way insulin works to lower it. This makes the insulin less effective at controlling your sugar levels.
Glucagon's labeled portfolio outnumbers Insulin Aspart
SPL source-record counts only. This page's band is minor · classes on file: Glucagon (Glucagon (Hypoglycemia Rescue)); Insulin Aspart (Rapid-Acting Insulin).
0 major · 0 moderate · 14 minor · 14 total
- Other minor peers for Glucagon
- Warfarin
- Indomethacin
- Glimepiride
- Insulin Degludec
0 major · 3 moderate · 8 minor · 11 total
- Other minor peers for Insulin Aspart
- Albuterol
- Clonidine
- Olanzapine
- Lithium
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.