Insulin Degludec and Liraglutide Interaction
Drug interaction information between Insulin Degludec and Liraglutide.
Insulin Degludec and Liraglutide have a documented moderate interaction in FDA labeling.
FDA drug labeling documents a moderate-severity interaction between Insulin Degludec and Liraglutide. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Liraglutide slows down the movement of food and medicine through your stomach, which can change how your body absorbs pills.
FDA Label Information
7.2 Effects of Delayed Gastric Emptying on Oral Medications Liraglutide-containing products, including XULTOPHY 100/3.6, cause a delay of gastric emptying, and thereby have the potential to impact the absorption of concomitantly administered oral medications. In clinical pharmacology trials, liraglutide did not affect the absorption of the tested orally administered medications to any clinically relevant degree [see Clinical Pharmacology ( 12.3 )] . Nonetheless, caution should be exercised when oral medications are concomitantly administered with liraglutide containing products.
Insulin Degludec Also Interacts With
- Fluoxetine moderate
- Pramlintide moderate
- Octreotide moderate
- Albuterol minor
- Clonidine minor
Frequently Asked Questions
What SPL severity band is on file for Insulin Degludec + Liraglutide?
Compiled FDA labeling labels this pair moderate. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Insulin Degludec has 12 labeled pairs on file vs Liraglutide's 1. In the moderate band specifically: Insulin Degludec has 4 (also Fluoxetine, Pramlintide, Octreotide); Liraglutide has 1.
What mechanism field is on file for Insulin Degludec and Liraglutide?
Liraglutide slows down the movement of food and medicine through your stomach, which can change how your body absorbs pills.
Insulin Degludec's labeled portfolio outnumbers Liraglutide
SPL source-record counts only. This page's band is moderate · classes on file: Insulin Degludec (Ultra-Long-Acting Insulin); Liraglutide (GLP-1 Receptor Agonist).
0 major · 4 moderate · 8 minor · 12 total
- Other moderate peers for Insulin Degludec
- Fluoxetine
- Pramlintide
- Octreotide
0 major · 1 moderate · 0 minor · 1 total
Liraglutide has no other moderate-band peer in this dataset besides Insulin Degludec.
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.