What the FDA labels say about taking them together
Clonidine and insulin degludec
Insulin degludec's FDA label of July 1, 2022 names clonidine in its drug interactions section; the clonidine labels PlainMeds reads (4) do not name insulin degludec. The insulin degludec label: “Drugs That May Increase or Decrease the Blood Glucose Lowering Effect of Insulin Degludec Drugs: Alcohol, beta-blockers, clonidine, and lithium salts.”
Check it at the source: the clonidine FDA label on DailyMed (effective March 30, 2026, Unichem Pharmaceuticals (USA), Inc.); the insulin degludec FDA label on DailyMed (effective July 1, 2022, Novo Nordisk Pharma, Inc.).
What does the clonidine label say about insulin degludec?
Clonidine's label (effective March 30, 2026) and its 3 other brand-application labels do not name insulin degludec in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (clonidine hydrochloride), Unichem Pharmaceuticals (USA), Inc., effective March 30, 2026 (SPL set 21bfa28f-20df-43fd-bb80-b720d3b40696), via openFDA; the full label on DailyMed
What does the insulin degludec label say about clonidine?
Insulin degludec label, drug interactionsDrugs That May Increase or Decrease the Blood Glucose Lowering Effect of Insulin Degludec Drugs: Alcohol, beta-blockers, clonidine, and lithium salts.
Source: FDA drug label (Insulin Degludec), Novo Nordisk Pharma, Inc., effective July 1, 2022 (SPL set c1be283d-4b1d-4996-b2a7-4488dbff3037), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Clonidine | Insulin degludec | |
|---|---|---|
| Labeled for | High blood pressure, ADHD, Pain | Type 2 diabetes, Type 1 diabetes |
| Boxed warning | No | No |
| Pharmacy cost (NADAC) | $0.0241 per tablet 0.1 mg tablet | $11.39 per mL 100 unit/mL pen |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once