Insulin Degludec and Clonidine Interaction
Drug interaction information between Insulin Degludec and Clonidine.
Insulin Degludec and Clonidine have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Insulin Degludec and Clonidine. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Clonidine can hide the body's normal warning signs of low blood sugar, such as a fast heartbeat. It can also make it harder to predict how much the insulin will lower your blood sugar.
FDA Label Information
( 7.1 ) • Anti-Adrenergic drugs (e.g., beta-blockers, clonidine, guanethidine, and reserpine): Hypoglycemia signs and symptoms may be reduced or absent. Drugs That May Increase or Decrease the Blood Glucose Lowering Effect of XULTOPHY 100/3.6 Drugs: Alcohol, beta-blockers, clonidine, and lithium salts. Drugs That May Blunt Signs and Symptoms of Hypoglycemia Drugs: Beta-blockers, clonidine, guanethidine, and reserpine Intervention: Increased frequency of glucose monitoring may be required when XULTOPHY 100/3.6 is coadministered with these drugs.
Insulin Degludec Also Interacts With
- Fluoxetine moderate
- Liraglutide moderate
- Pramlintide moderate
- Octreotide moderate
- Albuterol minor
Clonidine Also Interacts With
- Carvedilol moderate
- Metoprolol moderate
- Repaglinide moderate
- Sotalol moderate
- Amitriptyline minor
Frequently Asked Questions
What SPL severity band is on file for Insulin Degludec + Clonidine?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Clonidine has 29 labeled pairs on file vs Insulin Degludec's 12. In the minor band specifically: Insulin Degludec has 8 (also Albuterol, Olanzapine, Lithium, Clozapine); Clonidine has 25 (also Amitriptyline, Diltiazem, Verapamil, Haloperidol).
What mechanism field is on file for Insulin Degludec and Clonidine?
Clonidine can hide the body's normal warning signs of low blood sugar, such as a fast heartbeat. It can also make it harder to predict how much the insulin will lower your blood sugar.
Clonidine's labeled portfolio outnumbers Insulin Degludec
SPL source-record counts only. This page's band is minor · classes on file: Insulin Degludec (Ultra-Long-Acting Insulin); Clonidine (Central Alpha-2 Agonist).
0 major · 4 moderate · 8 minor · 12 total
- Other minor peers for Insulin Degludec
- Albuterol
- Olanzapine
- Lithium
- Clozapine
0 major · 4 moderate · 25 minor · 29 total
- Other minor peers for Clonidine
- Amitriptyline
- Diltiazem
- Verapamil
- Haloperidol
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.