Insulin Degludec and Albuterol Interaction
Drug interaction information between Insulin Degludec and Albuterol.
Insulin Degludec and Albuterol have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Insulin Degludec and Albuterol. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Albuterol can decrease the blood-sugar-lowering effect of insulin. This can lead to higher blood sugar levels while you are using the medication.
FDA Label Information
Drugs That May Decrease the Blood Glucose Lowering Effect of XULTOPHY 100/3.6 Drugs: Atypical antipsychotics (e.g., olanzapine and clozapine), corticosteroids, danazol, diuretics, estrogens, glucagon, isoniazid, niacin, oral contraceptives, phenothiazines, progestogens (e.g., in oral contraceptives), protease inhibitors, somatropin, sympathomimetic agents (e.g., albuterol, epinephrine, terbutaline), and thyroid hormones.
Insulin Degludec Also Interacts With
- Fluoxetine moderate
- Liraglutide moderate
- Pramlintide moderate
- Octreotide moderate
- Clonidine minor
Albuterol Also Interacts With
- Theophylline major
- Albuterol/Ipratropium moderate
- Atomoxetine moderate
- Digoxin minor
- Glimepiride minor
Frequently Asked Questions
What SPL severity band is on file for Insulin Degludec + Albuterol?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Albuterol has 16 labeled pairs on file vs Insulin Degludec's 12. In the minor band specifically: Insulin Degludec has 8 (also Clonidine, Olanzapine, Lithium, Clozapine); Albuterol has 13 (also Digoxin, Glimepiride, Insulin Aspart, Insulin Detemir).
What mechanism field is on file for Insulin Degludec and Albuterol?
Albuterol can decrease the blood-sugar-lowering effect of insulin. This can lead to higher blood sugar levels while you are using the medication.
Albuterol carries more major-labeled pairs than Insulin Degludec
SPL source-record counts only. This page's band is minor · classes on file: Insulin Degludec (Ultra-Long-Acting Insulin); Albuterol (Short-Acting Beta-2 Agonist).
Albuterol has 1 major-labeled pair vs Insulin Degludec's 0. This page itself is in the minor band, not the major band.
0 major · 4 moderate · 8 minor · 12 total
- Other minor peers for Insulin Degludec
- Clonidine
- Olanzapine
- Lithium
- Clozapine
1 major · 2 moderate · 13 minor · 16 total
- Other minor peers for Albuterol
- Digoxin
- Glimepiride
- Insulin Aspart
- Insulin Detemir
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.