Insulin Degludec and Fluoxetine Interaction
Drug interaction information between Insulin Degludec and Fluoxetine.
Insulin Degludec and Fluoxetine have a documented moderate interaction in FDA labeling.
FDA drug labeling documents a moderate-severity interaction between Insulin Degludec and Fluoxetine. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Fluoxetine can increase the effect of insulin, which makes your blood sugar more likely to drop to unsafe levels.
FDA Label Information
Drugs That May Increase the Risk of Hypoglycemia Drugs: Antidiabetic agents, ACE inhibitors, angiotensin II receptor blocking agents, disopyramide, fibrates, fluoxetine, monoamine oxidase inhibitors, pentoxifylline, pramlintide, salicylates, somatostatin analogs (e.g., octreotide), and sulfonamide antibiotics Intervention: Dosage reductions and increased frequency of glucose monitoring may be required when XULTOPHY 100/3.6 is coadministered with these drugs.
Insulin Degludec Also Interacts With
- Liraglutide moderate
- Pramlintide moderate
- Octreotide moderate
- Albuterol minor
- Clonidine minor
Fluoxetine Also Interacts With
- Aspirin major
- Warfarin major
- Olanzapine major
- Pimozide major
- Thioridazine major
Frequently Asked Questions
What SPL severity band is on file for Insulin Degludec + Fluoxetine?
Compiled FDA labeling labels this pair moderate. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Fluoxetine has 68 labeled pairs on file vs Insulin Degludec's 12. In the moderate band specifically: Insulin Degludec has 4 (also Liraglutide, Pramlintide, Octreotide); Fluoxetine has 19 (also Alprazolam, Diazepam, Carbamazepine, Haloperidol).
What mechanism field is on file for Insulin Degludec and Fluoxetine?
Fluoxetine can increase the effect of insulin, which makes your blood sugar more likely to drop to unsafe levels.
Fluoxetine carries more major-labeled pairs than Insulin Degludec
SPL source-record counts only. This page's band is moderate · classes on file: Insulin Degludec (Ultra-Long-Acting Insulin); Fluoxetine (Selective Serotonin Reuptake Inhibitor (SSRI)).
Fluoxetine has 6 major-labeled pairs vs Insulin Degludec's 0. This page itself is in the moderate band, not the major band.
0 major · 4 moderate · 8 minor · 12 total
- Other moderate peers for Insulin Degludec
- Liraglutide
- Pramlintide
- Octreotide
6 major · 19 moderate · 43 minor · 68 total
- Other moderate peers for Fluoxetine
- Alprazolam
- Diazepam
- Carbamazepine
- Haloperidol
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.