Insulin Degludec and Fluoxetine Interaction
Drug interaction information between Insulin Degludec and Fluoxetine.
Insulin Degludec and Fluoxetine have a documented moderate interaction in FDA labeling.
FDA drug labeling documents a moderate-severity interaction between Insulin Degludec and Fluoxetine. Major interactions are generally avoided, moderate ones may need monitoring or a dose adjustment, and minor ones are usually low-risk. This page shows the documented mechanism and guidance. Label-documented interactions are not a complete safety review, so always confirm your own medications with a pharmacist or doctor. Educational information, not medical advice.
How They Interact
Fluoxetine can increase the effect of insulin, which makes your blood sugar more likely to drop to unsafe levels.
What To Do
Check your blood sugar more often and talk to your doctor about adjusting your insulin dose.
FDA Label Information
Drugs That May Increase the Risk of Hypoglycemia Drugs: Antidiabetic agents, ACE inhibitors, angiotensin II receptor blocking agents, disopyramide, fibrates, fluoxetine, monoamine oxidase inhibitors, pentoxifylline, pramlintide, salicylates, somatostatin analogs (e.g., octreotide), and sulfonamide antibiotics Intervention: Dosage reductions and increased frequency of glucose monitoring may be required when XULTOPHY 100/3.6 is coadministered with these drugs.
Insulin Degludec Also Interacts With
- Liraglutide moderate
- Pramlintide moderate
- Octreotide moderate
- Albuterol minor
- Clonidine minor
Fluoxetine Also Interacts With
- Aspirin major
- Warfarin major
- Olanzapine major
- Pimozide major
- Thioridazine major
Frequently Asked Questions
Can I take Insulin Degludec and Fluoxetine together?
This is a moderate interaction. Check your blood sugar more often and talk to your doctor about adjusting your insulin dose.
How serious is the interaction between Insulin Degludec and Fluoxetine?
This interaction is classified as "moderate" severity by the FDA. Moderate interactions may worsen your condition or change how your medications work.
Why do Insulin Degludec and Fluoxetine interact?
Fluoxetine can increase the effect of insulin, which makes your blood sugar more likely to drop to unsafe levels.
Understanding the Insulin Degludec and Fluoxetine Interaction
FDA-approved prescribing information for these two drugs flags their combination as a moderate-severity interaction. Insulin Degludec belongs to the Ultra-Long-Acting Insulin class and Fluoxetine belongs to the Selective Serotonin Reuptake Inhibitor (SSRI) class - two categories that can collide when co-prescribed. The mechanism described in FDA labeling is: Fluoxetine can increase the effect of insulin, which makes your blood sugar more likely to drop to unsafe levels. Severity tiers matter: major flags generally advise avoidance, moderate flags often require monitoring or dose adjustment, and minor flags may only call for awareness.
Context around a specific patient determines real-world impact. Insulin Degludec has 12 total documented interactions on file in this dataset, and Fluoxetine has 68. Each additional medication compounds the interaction surface, which is why pharmacists run full-profile checks rather than evaluating one pair at a time. FDA-derived guidance for this pair is: Check your blood sugar more often and talk to your doctor about adjusting your insulin dose. Timing of doses, renal and hepatic function, age, and other concurrent prescriptions all shape whether a labeled interaction matters clinically.
An interaction flag is not a verdict. A large share of labeled interactions are managed routinely in clinical practice, the fix may be as simple as spacing doses or adding a monitoring test. Others require the prescriber to choose a different medication entirely. This page surfaces FDA-sourced labeling and openFDA data for educational purposes only; it is not medical advice and cannot account for your full clinical picture. Never start, stop, or adjust either Insulin Degludec or Fluoxetine based on a web page, speak with your prescriber or pharmacist before making any change.
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. Always consult your healthcare provider about drug interactions.
Read our methodology - how this data is sourced, computed, and verified.