What the FDA labels say about taking them together
Glucagon and indomethacin
Glucagon's FDA label of August 11, 2026 names indomethacin in its drug interactions section; the indomethacin labels PlainMeds reads (4) do not name glucagon. The glucagon label: “The concomitant use of indomethacin and Glucagon for Injection may lead to hypoglycemia.”
Check it at the source: the glucagon FDA label on DailyMed (effective August 11, 2026, Amphastar Pharmaceuticals, Inc.); the indomethacin FDA label on DailyMed (effective December 19, 2025, Glenmark Pharmaceuticals Inc., USA).
What does the glucagon label say about indomethacin?
Glucagon label, drug interactionsClinical Impact: In patients taking indomethacin, Glucagon for Injection may lose its ability to raise blood glucose or may even produce hypoglycemia. Intervention: Monitor blood glucose levels during glucagon treatment of patients taking indomethacin.
Glucagon label (Fresenius Kabi USA, LLC, April 1, 2022), drug interactionsClinical Impact: The concomitant use of indomethacin and Glucagon for Injection may lead to hypoglycemia. Intervention: Monitor blood glucose levels during glucagon treatment of patients taking indomethacin.
Gvoke Hypopen 0.5 Mg Auto-Injector label (Xeris Pharmaceuticals, Inc., December 23, 2025), drug interactionsIndomethacin Clincial Impact: In patients taking indomethacin, GVOKE may lose its ability to raise blood glucose or may even produce hypoglycemia.
Source: FDA drug label (Glucagon, NDA201849), Fresenius Kabi USA, LLC, effective April 1, 2022 (SPL set 8c8acad6-44cc-43aa-966b-027e053be8f5), via openFDA
Source: FDA drug label (Gvoke Hypopen 0.5 Mg Auto-Injector, NDA212097), Xeris Pharmaceuticals, Inc., effective December 23, 2025 (SPL set 92385737-dbad-98c5-e053-2995a90a2805), via openFDA
Source: FDA drug label (Baqsimi, NDA210134), Amphastar Pharmaceuticals, Inc., effective August 6, 2025 (SPL set f1f5df9b-872f-44e5-a18f-f0b68e7e9254), via openFDA
Source: FDA drug label (Glucagon), Amphastar Pharmaceuticals, Inc., effective August 11, 2026 (SPL set 8cc40354-b5ac-45b6-a211-93b44444f2a3), via openFDA; the full label on DailyMed
What does the indomethacin label say about glucagon?
Indomethacin's label (effective December 19, 2025) and its 3 other brand-application labels do not name glucagon in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Indomethacin), Glenmark Pharmaceuticals Inc., USA, effective December 19, 2025 (SPL set f7ed39e2-5431-4e47-935c-c7441d058f94), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Glucagon | Indomethacin | |
|---|---|---|
| Labeled for | n/a | Rheumatoid arthritis, Osteoarthritis |
| Boxed warning | No | Yes |
| Pharmacy cost (NADAC) | $154.20 per kit 1 mg emergency kit | $0.210 per capsule 75 mg capsule |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once