Glucagon and Indomethacin Interaction
Drug interaction information between Glucagon and Indomethacin.
Glucagon and Indomethacin have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Glucagon and Indomethacin. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Indomethacin can prevent glucagon from raising your blood sugar and may even cause your blood sugar to drop too low.
FDA Label Information
Indomethacin Clinical Impact: In patients taking indomethacin, Glucagon for Injection may lose its ability to raise blood glucose or may even produce hypoglycemia. Intervention: Monitor blood glucose levels during glucagon treatment of patients taking indomethacin. ( 7 ) • Indomethacin : In patients taking indomethacin Glucagon for Injection may lose its ability to raise glucose or may produce hypoglycemia.
Glucagon Also Interacts With
- Warfarin minor
- Glimepiride minor
- Insulin Aspart minor
- Insulin Degludec minor
- Insulin Detemir minor
Indomethacin Also Interacts With
- Methotrexate moderate
- Diflunisal moderate
- Heparin moderate
- Perindopril moderate
- Warfarin moderate
Frequently Asked Questions
What SPL severity band is on file for Glucagon + Indomethacin?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Indomethacin has 35 labeled pairs on file vs Glucagon's 14. In the minor band specifically: Glucagon has 14 (also Warfarin, Glimepiride, Insulin Aspart, Insulin Degludec); Indomethacin has 30 (also Meloxicam, Aspirin, Diclofenac, Cyclosporine).
What mechanism field is on file for Glucagon and Indomethacin?
Indomethacin can prevent glucagon from raising your blood sugar and may even cause your blood sugar to drop too low.
Indomethacin's labeled portfolio outnumbers Glucagon
SPL source-record counts only. This page's band is minor · classes on file: Glucagon (Glucagon (Hypoglycemia Rescue)); Indomethacin (Nonsteroidal Anti-Inflammatory Drug (NSAID)).
0 major · 0 moderate · 14 minor · 14 total
- Other minor peers for Glucagon
- Warfarin
- Glimepiride
- Insulin Aspart
- Insulin Degludec
0 major · 5 moderate · 30 minor · 35 total
- Other minor peers for Indomethacin
- Meloxicam
- Aspirin
- Diclofenac
- Cyclosporine
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.