Insulin Degludec and Olanzapine Interaction
Drug interaction information between Insulin Degludec and Olanzapine.
Insulin Degludec and Olanzapine have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Insulin Degludec and Olanzapine. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Olanzapine can reduce the ability of insulin to lower your blood sugar. This can result in higher blood sugar levels.
FDA Label Information
Drugs That May Decrease the Blood Glucose Lowering Effect of XULTOPHY 100/3.6 Drugs: Atypical antipsychotics (e.g., olanzapine and clozapine), corticosteroids, danazol, diuretics, estrogens, glucagon, isoniazid, niacin, oral contraceptives, phenothiazines, progestogens (e.g., in oral contraceptives), protease inhibitors, somatropin, sympathomimetic agents (e.g., albuterol, epinephrine, terbutaline), and thyroid hormones.
Insulin Degludec Also Interacts With
- Fluoxetine moderate
- Liraglutide moderate
- Pramlintide moderate
- Octreotide moderate
- Albuterol minor
Olanzapine Also Interacts With
- Fluoxetine major
- Tetrabenazine moderate
- Omeprazole minor
- Warfarin minor
- Diazepam minor
Frequently Asked Questions
What SPL severity band is on file for Insulin Degludec + Olanzapine?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Olanzapine has 26 labeled pairs on file vs Insulin Degludec's 12. In the minor band specifically: Insulin Degludec has 8 (also Albuterol, Clonidine, Lithium, Clozapine); Olanzapine has 24 (also Omeprazole, Warfarin, Diazepam, Carbamazepine).
What mechanism field is on file for Insulin Degludec and Olanzapine?
Olanzapine can reduce the ability of insulin to lower your blood sugar. This can result in higher blood sugar levels.
Olanzapine carries more major-labeled pairs than Insulin Degludec
SPL source-record counts only. This page's band is minor · classes on file: Insulin Degludec (Ultra-Long-Acting Insulin); Olanzapine (Atypical Antipsychotic).
Olanzapine has 1 major-labeled pair vs Insulin Degludec's 0. This page itself is in the minor band, not the major band.
0 major · 4 moderate · 8 minor · 12 total
1 major · 1 moderate · 24 minor · 26 total
- Other minor peers for Olanzapine
- Omeprazole
- Warfarin
- Diazepam
- Carbamazepine
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.