Insulin Degludec and Lithium Interaction
Drug interaction information between Insulin Degludec and Lithium.
Insulin Degludec and Lithium have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Insulin Degludec and Lithium. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Lithium can cause your blood sugar levels to either rise or fall in ways that are hard to predict.
FDA Label Information
Drugs That May Increase or Decrease the Blood Glucose Lowering Effect of XULTOPHY 100/3.6 Drugs: Alcohol, beta-blockers, clonidine, and lithium salts.
Insulin Degludec Also Interacts With
- Fluoxetine moderate
- Liraglutide moderate
- Pramlintide moderate
- Octreotide moderate
- Albuterol minor
Lithium Also Interacts With
- Amlodipine/Benazepril major
- Risperidone major
- Amiloride moderate
- Amiodarone moderate
- Amlodipine/Valsartan moderate
Frequently Asked Questions
What SPL severity band is on file for Insulin Degludec + Lithium?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Lithium has 90 labeled pairs on file vs Insulin Degludec's 12. In the minor band specifically: Insulin Degludec has 8 (also Albuterol, Clonidine, Olanzapine, Clozapine); Lithium has 65 (also Aripiprazole, Asenapine, Canagliflozin, Candesartan).
What mechanism field is on file for Insulin Degludec and Lithium?
Lithium can cause your blood sugar levels to either rise or fall in ways that are hard to predict.
Lithium carries more major-labeled pairs than Insulin Degludec
SPL source-record counts only. This page's band is minor · classes on file: Insulin Degludec (Ultra-Long-Acting Insulin); Lithium (Mood Stabilizer).
Lithium has 2 major-labeled pairs vs Insulin Degludec's 0. This page itself is in the minor band, not the major band.
0 major · 4 moderate · 8 minor · 12 total
- Other minor peers for Insulin Degludec
- Albuterol
- Clonidine
- Olanzapine
- Clozapine
2 major · 23 moderate · 65 minor · 90 total
- Other minor peers for Lithium
- Aripiprazole
- Asenapine
- Canagliflozin
- Candesartan
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.