Gemfibrozil and Colchicine Interaction
Drug interaction information between Gemfibrozil and Colchicine.
Gemfibrozil and Colchicine have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Gemfibrozil and Colchicine. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Using these drugs together increases the chance of developing severe muscle breakdown known as rhabdomyolysis.
FDA Label Information
Other Lipid-Lowering Drugs: fibrates, gemfibrozil Digitalis Glycosides: digoxin P-gp substrate; rhabdomyolysis has been reported Coadministration of P-gp and/or CYP3A4 inhibitors (e.g., clarithromycin or cyclosporine) have been demonstrated to alter the concentration of colchicine.
Gemfibrozil Also Interacts With
- Ezetimibe major
- Ezetimibe/Simvastatin major
- Repaglinide major
- Simvastatin major
- Atorvastatin moderate
Colchicine Also Interacts With
- Clarithromycin major
- Darunavir major
- Itraconazole major
- Nirmatrelvir/Ritonavir major
- Atorvastatin moderate
Frequently Asked Questions
What SPL severity band is on file for Gemfibrozil + Colchicine?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Colchicine has 28 labeled pairs on file vs Gemfibrozil's 20. In the minor band specifically: Gemfibrozil has 8 (also Colestipol, Enzalutamide, Metformin/Pioglitazone, Montelukast); Colchicine has 15 (also Estradiol, Diltiazem, Norethindrone, Ketoconazole).
What mechanism field is on file for Gemfibrozil and Colchicine?
Using these drugs together increases the chance of developing severe muscle breakdown known as rhabdomyolysis.
Colchicine's labeled portfolio outnumbers Gemfibrozil
SPL source-record counts only. This page's band is minor · classes on file: Gemfibrozil (Fibrate); Colchicine (Anti-Gout Agent).
4 major · 8 moderate · 8 minor · 20 total
- Other minor peers for Gemfibrozil
- Colestipol
- Enzalutamide
- Metformin/Pioglitazone
- Montelukast
4 major · 9 moderate · 15 minor · 28 total
- Other minor peers for Colchicine
- Estradiol
- Diltiazem
- Norethindrone
- Ketoconazole
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.