What the FDA labels say about taking them together
Colchicine and diltiazem
Colchicine's FDA label (Lodoco) of August 13, 2026 names diltiazem in its drug interactions section; the diltiazem labels PlainMeds reads (4) do not name colchicine. The colchicine label: “Significant increase in colchicine plasma concentration is anticipated.”
Check it at the source: the colchicine FDA label on DailyMed (effective July 22, 2025, Aurobindo Pharma Limited); the diltiazem FDA label on DailyMed (effective August 7, 2026, Bausch Health US, LLC).
What does the colchicine label say about diltiazem?
Lodoco label (AGEPHA Pharma USA, LLC, August 13, 2026), drug interactionsDrug class: Moderate CYP3A4 Inhibitors amprenavir aprepitant diltiazem erythromycin fluconazole, fosamprenavir (prodrug of amprenavir) verapamil; Outcome/effect: Significant increase in colchicine plasma concentration is anticipated.; Clinical comment: Monitor patients receiving moderate CYP3A4 inhibitors for signs of colchicine toxicity. Avoid use in patients with existing renal or hepatic impairment [see Warnings and Precautions (5)].
Source: FDA drug label (Lodoco, NDA215727), AGEPHA Pharma USA, LLC, effective August 13, 2026 (SPL set ff06d68f-d65f-d097-e053-6294a90a7e5f), via openFDA
Source: FDA drug label (Colchicine), Aurobindo Pharma Limited, effective July 22, 2025 (SPL set dd93a40f-92ab-47ac-9083-b8a7a0b18ad6), via openFDA; the full label on DailyMed
What does the diltiazem label say about colchicine?
Diltiazem's label (effective August 7, 2026) and its 3 other brand-application labels do not name colchicine in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (TIAZAC EXTENDED RELEASE), Bausch Health US, LLC, effective August 7, 2026 (SPL set c567fe7e-887e-4291-a0d1-2dd3f25cbf25), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Colchicine | Diltiazem | |
|---|---|---|
| Labeled for | Gout | High blood pressure, Angina, Atrial fibrillation |
| Boxed warning | No | No |
| Pharmacy cost (NADAC) | $0.122 per tablet 0.6 mg tablet | $0.144 per capsule 24h ER(cd) 120 mg capsule |
| Shortage now | No current entry | A presentation being discontinued |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once