Colchicine and Ketoconazole Interaction
Drug interaction information between Colchicine and Ketoconazole.
Colchicine and Ketoconazole have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Colchicine and Ketoconazole. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Ketoconazole significantly slows down the removal of colchicine from your system. This can cause the amount of colchicine in your blood to more than double.
FDA Label Information
Drug Interactions: Pharmacokinetic Parameters for Colchicine Tablets in the Presence of the Coadministered Drug Coadministered Drug Dose of Coadministered Drug (mg) Dose of Colchicine Tablets (mg) N % Change in Colchicine Concentrations from Baseline (Range: Min – Max) C max AUC 0-t Cyclosporine 100 mg single dose 0.6 mg single dose 23 270.0 (62.0 to 606.9) 259.0 (75.8 to 511.9) Clarithromycin 250 mg twice daily, 7 days 0.6 mg single dose 23 227.2 (65.7 to 591.1) 281.5 (88.7 to 851.6) Ketoconazole 200 mg twice daily, 5 days 0.6 mg single dose 24 101.7 (19.6 to 219.0) 212.2 (76.7 to 419.6)...
Colchicine Also Interacts With
- Clarithromycin major
- Darunavir major
- Itraconazole major
- Nirmatrelvir/Ritonavir major
- Atorvastatin moderate
Ketoconazole Also Interacts With
- Alfuzosin major
- Dronedarone major
- Ranolazine major
- Saxagliptin major
- Sildenafil major
Frequently Asked Questions
What SPL severity band is on file for Colchicine + Ketoconazole?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Ketoconazole has 113 labeled pairs on file vs Colchicine's 28. In the minor band specifically: Colchicine has 15 (also Estradiol, Diltiazem, Norethindrone, Verapamil); Ketoconazole has 85 (also Abiraterone, Acetaminophen/Oxycodone, Alosetron, Amphotericin B).
What mechanism field is on file for Colchicine and Ketoconazole?
Ketoconazole significantly slows down the removal of colchicine from your system. This can cause the amount of colchicine in your blood to more than double.
Ketoconazole carries more major-labeled pairs than Colchicine
SPL source-record counts only. This page's band is minor · classes on file: Colchicine (Anti-Gout Agent); Ketoconazole (Azole Antifungal).
Ketoconazole has 6 major-labeled pairs vs Colchicine's 4. This page itself is in the minor band, not the major band.
4 major · 9 moderate · 15 minor · 28 total
- Other minor peers for Colchicine
- Estradiol
- Diltiazem
- Norethindrone
- Verapamil
6 major · 22 moderate · 85 minor · 113 total
- Other minor peers for Ketoconazole
- Abiraterone
- Acetaminophen/Oxycodone
- Alosetron
- Amphotericin B
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.