colchicine vs gemfibrozil
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Side-by-side comparison of colchicine and gemfibrozil. Data from FDA drug databases (Orange Book, NDC Directory, recalls, shortages) covering 20,000+ approved drugs, plus CMS pricing; see our methodology.
minor Known Drug Interaction
Other Lipid-Lowering Drugs: fibrates, gemfibrozil Digitalis Glycosides: digoxin P-gp substrate; rhabdomyolysis has been reported Coadministration of P-gp and/or CYP3A4 inhibitors (e.g., clarithromycin or cyclosporine) have been demonstrated to alter the concentration of colchicine.
Colcrys, Mitigare
Lopid
Colchicine is a medicine used to prevent or treat gout flares and Familial Mediterranean Fever (FMF). It works by reducing inflammation and pain.
Gemfibrozil is a medicine that helps lower high triglyceride levels in your blood. It can also help reduce the risk of heart disease in some people.
Colchicine is used to prevent and treat gout flares in adults. Gout flares cause sudden, severe pain, redness, and swelling in your joints. Colchicine is also used to treat Familial Mediterranean Fever (FMF) in adults and children ages 4 and older. FMF causes recurring fevers and pain in the abdomen, chest, or joints.
This medicine is used to treat very high triglyceride levels in adults when diet alone doesn't work. High triglycerides can increase your risk of pancreatitis. Gemfibrozil can also lower the risk of heart disease in some people with specific cholesterol problems.
Colchicine reduces inflammation in the body. It does this by blocking certain processes that cause swelling and pain. This helps to relieve gout flares and manage FMF symptoms.
Gemfibrozil belongs to a class of drugs called fibrates. It works by decreasing the amount of triglycerides your body makes. It also helps to increase HDL (good) cholesterol.
- • Diarrhea
- • Abdominal pain
- • Nausea
- • Vomiting
- • Upset stomach
- • Indigestion
- • Abdominal pain
- Diarrhoea 2,660
- Nausea 1,940
- Fatigue 1,747
- Dyspnoea 1,467
- Acute Kidney Injury 1,436
- Nausea 883
- Fatigue 825
- Diarrhoea 726
- Pain 693
- Dizziness 617
Taking too much colchicine can be fatal in both adults and children. Keep this medicine out of the reach of children. Colchicine can also cause serious blood problems and muscle weakness. Certain medicines can interact with colchicine and cause life-threatening problems. Talk to your doctor about all the medicines you take.
This medicine may increase your risk of gallbladder problems, including the need for surgery. Before taking gemfibrozil, tell your doctor if you have liver or kidney problems. You should not take this medicine with simvastatin, repaglinide, dasabuvir, or selexipag.
Tell your doctor if you are pregnant or plan to become pregnant. Colchicine may harm your unborn baby. It is not known if colchicine passes into breast milk. Talk to your doctor about the risks and benefits of taking colchicine while breastfeeding.
Tell your doctor if you are pregnant, plan to become pregnant, or are breastfeeding. It is not known if gemfibrozil can harm your unborn baby. It is also not known if gemfibrozil passes into breast milk.
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How to Read This colchicine vs gemfibrozil Comparison
colchicine is classified in the Anti-Gout Agent drug class, while gemfibrozil sits within the Fibrate class. Drugs from different classes work through distinct mechanisms, so a head-to-head comparison illustrates trade-offs rather than equivalence. Both drugs are prescription-only, so a licensed provider must authorize use.
Adverse event totals above are pulled from the FDA's Adverse Event Reporting System (FAERS). For these top-ranked reactions alone, colchicine has 9,250 submissions while gemfibrozil has 3,744. Those figures reflect cumulative reporting volume, not per-patient risk, so older, widely dispensed drugs typically look worse on count alone. These two drugs have a known minor interaction flagged in FDA labeling, attributed to using these drugs together increases the chance of developing severe muscle breakdown known as rhabdomyolysis.. Serious warnings, pregnancy guidance, and contraindications can differ even when indications overlap.
A table cannot represent individual circumstances. Data here is sourced from FDA Structured Product Labels (SPL) and FAERS, both of which update as manufacturers and clinicians submit new information. This registry does not provide medical, treatment, substitution, or medication-change directions for colchicine or gemfibrozil.
Registry boundary: This comparison displays source-record fields and does not provide individualized medical direction.