Gemfibrozil and Montelukast Interaction
Drug interaction information between Gemfibrozil and Montelukast.
Gemfibrozil and Montelukast have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Gemfibrozil and Montelukast. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
These drugs do not have a meaningful impact on how the body breaks each other down.
FDA Label Information
DRUG INTERACTIONS No dose adjustment is needed when montelukast sodium is co-administered with theophylline, prednisone, prednisolone, oral contraceptives, terfenadine, digoxin, warfarin, gemfibrozil, itraconazole, thyroid hormones, sedative hypnotics, non-steroidal anti-inflammatory agents, benzodiazepines, decongestants, and Cytochrome P450 (CYP) enzyme inducers [see Clinical Pharmacology (12.3)] .
Gemfibrozil Also Interacts With
- Ezetimibe major
- Ezetimibe/Simvastatin major
- Repaglinide major
- Simvastatin major
- Atorvastatin moderate
Montelukast Also Interacts With
- Prednisone minor
- Warfarin minor
- Prednisolone minor
- Itraconazole minor
- Digoxin minor
Frequently Asked Questions
What SPL severity band is on file for Gemfibrozil + Montelukast?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Gemfibrozil has 20 labeled pairs on file vs Montelukast's 8. In the minor band specifically: Gemfibrozil has 8 (also Colchicine, Colestipol, Enzalutamide, Metformin/Pioglitazone); Montelukast has 8 (also Prednisone, Warfarin, Prednisolone, Itraconazole).
What mechanism field is on file for Gemfibrozil and Montelukast?
These drugs do not have a meaningful impact on how the body breaks each other down.
Gemfibrozil carries more major-labeled pairs than Montelukast
SPL source-record counts only. This page's band is minor · classes on file: Gemfibrozil (Fibrate); Montelukast (Leukotriene Receptor Antagonist).
Gemfibrozil has 4 major-labeled pairs vs Montelukast's 0. This page itself is in the minor band, not the major band.
4 major · 8 moderate · 8 minor · 20 total
- Other minor peers for Gemfibrozil
- Colchicine
- Colestipol
- Enzalutamide
- Metformin/Pioglitazone
0 major · 0 moderate · 8 minor · 8 total
- Other minor peers for Montelukast
- Prednisone
- Warfarin
- Prednisolone
- Itraconazole
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.