Colchicine and Estradiol Interaction
Drug interaction information between Colchicine and Estradiol.
Colchicine and Estradiol have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Colchicine and Estradiol. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Estradiol can change how your body processes colchicine, which might lead to higher levels of the drug in your system.
FDA Label Information
Drug Interactions: Pharmacokinetic Parameters for Colchicine Tablets in the Presence of the Coadministered Drug Coadministered Drug Dose of Coadministered Drug (mg) Dose of Colchicine Tablets (mg) N % Change in Colchicine Concentrations from Baseline (Range: Min – Max) C max AUC 0-t Cyclosporine 100 mg single dose 0.6 mg single dose 23 270.0 (62.0 to 606.9) 259.0 (75.8 to 511.9) Clarithromycin 250 mg twice daily, 7 days 0.6 mg single dose 23 227.2 (65.7 to 591.1) 281.5 (88.7 to 851.6) Ketoconazole 200 mg twice daily, 5 days 0.6 mg single dose 24 101.7 (19.6 to 219.0) 212.2 (76.7 to 419.6)...
Colchicine Also Interacts With
- Clarithromycin major
- Darunavir major
- Itraconazole major
- Nirmatrelvir/Ritonavir major
- Atorvastatin moderate
Estradiol Also Interacts With
- Drospirenone/Ethinyl Estradiol major
- Glecaprevir/Pibrentasvir moderate
- Etonogestrel moderate
- Tacrolimus Topical moderate
- Rosuvastatin minor
Frequently Asked Questions
What SPL severity band is on file for Colchicine + Estradiol?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Estradiol has 54 labeled pairs on file vs Colchicine's 28. In the minor band specifically: Colchicine has 15 (also Diltiazem, Norethindrone, Ketoconazole, Verapamil); Estradiol has 50 (also Rosuvastatin, Lamotrigine, Topiramate, Tizanidine).
What mechanism field is on file for Colchicine and Estradiol?
Estradiol can change how your body processes colchicine, which might lead to higher levels of the drug in your system.
Colchicine carries more major-labeled pairs than Estradiol
SPL source-record counts only. This page's band is minor · classes on file: Colchicine (Anti-Gout Agent); Estradiol (Estrogen Hormone).
Colchicine has 4 major-labeled pairs vs Estradiol's 1. This page itself is in the minor band, not the major band.
4 major · 9 moderate · 15 minor · 28 total
- Other minor peers for Colchicine
- Diltiazem
- Norethindrone
- Ketoconazole
- Verapamil
1 major · 3 moderate · 50 minor · 54 total
- Other minor peers for Estradiol
- Rosuvastatin
- Lamotrigine
- Topiramate
- Tizanidine
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.