Colchicine and Norethindrone Interaction
Drug interaction information between Colchicine and Norethindrone.
Colchicine and Norethindrone have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Colchicine and Norethindrone. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
There is no known significant interaction between these two medications. They do not interfere with how each other is processed by the body.
FDA Label Information
Drug Interactions: Pharmacokinetic Parameters for Colchicine Tablets in the Presence of the Coadministered Drug Coadministered Drug Dose of Coadministered Drug (mg) Dose of Colchicine Tablets (mg) N % Change in Colchicine Concentrations from Baseline (Range: Min – Max) C max AUC 0-t Cyclosporine 100 mg single dose 0.6 mg single dose 23 270.0 (62.0 to 606.9) 259.0 (75.8 to 511.9) Clarithromycin 250 mg twice daily, 7 days 0.6 mg single dose 23 227.2 (65.7 to 591.1) 281.5 (88.7 to 851.6) Ketoconazole 200 mg twice daily, 5 days 0.6 mg single dose 24 101.7 (19.6 to 219.0) 212.2 (76.7 to 419.6)...
Colchicine Also Interacts With
- Clarithromycin major
- Darunavir major
- Itraconazole major
- Nirmatrelvir/Ritonavir major
- Atorvastatin moderate
Norethindrone Also Interacts With
- Voriconazole major
- Atorvastatin minor
- Colesevelam minor
- Darunavir minor
- Fluconazole minor
Frequently Asked Questions
What SPL severity band is on file for Colchicine + Norethindrone?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Colchicine has 28 labeled pairs on file vs Norethindrone's 10. In the minor band specifically: Colchicine has 15 (also Estradiol, Diltiazem, Ketoconazole, Verapamil); Norethindrone has 9 (also Atorvastatin, Colesevelam, Darunavir, Fluconazole).
What mechanism field is on file for Colchicine and Norethindrone?
There is no known significant interaction between these two medications. They do not interfere with how each other is processed by the body.
Colchicine carries more major-labeled pairs than Norethindrone
SPL source-record counts only. This page's band is minor · classes on file: Colchicine (Anti-Gout Agent); Norethindrone (Progestin-Only Oral Contraceptive).
Colchicine has 4 major-labeled pairs vs Norethindrone's 1. This page itself is in the minor band, not the major band.
4 major · 9 moderate · 15 minor · 28 total
- Other minor peers for Colchicine
- Estradiol
- Diltiazem
- Ketoconazole
- Verapamil
1 major · 0 moderate · 9 minor · 10 total
- Other minor peers for Norethindrone
- Atorvastatin
- Colesevelam
- Darunavir
- Fluconazole
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.