Gemfibrozil and Colestipol Interaction
Drug interaction information between Gemfibrozil and Colestipol.
Gemfibrozil and Colestipol have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Gemfibrozil and Colestipol. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Colestipol can trap gemfibrozil in the gut, which significantly lowers the amount of medicine that enters your body.
FDA Label Information
The absorption of tetracycline, furosemide, penicillin G, hydrochlorothiazide, and gemfibrozil was significantly decreased when given simultaneously with colestipol hydrochloride; these drugs were not tested to determine the effect of administration one hour before colestipol hydrochloride.
Gemfibrozil Also Interacts With
- Ezetimibe major
- Ezetimibe/Simvastatin major
- Repaglinide major
- Simvastatin major
- Atorvastatin moderate
Colestipol Also Interacts With
- Olmesartan moderate
- Furosemide minor
- Aspirin minor
- Propranolol minor
- Warfarin minor
Frequently Asked Questions
What SPL severity band is on file for Gemfibrozil + Colestipol?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Colestipol has 24 labeled pairs on file vs Gemfibrozil's 20. In the minor band specifically: Gemfibrozil has 8 (also Colchicine, Enzalutamide, Metformin/Pioglitazone, Montelukast); Colestipol has 23 (also Furosemide, Aspirin, Propranolol, Warfarin).
What mechanism field is on file for Gemfibrozil and Colestipol?
Colestipol can trap gemfibrozil in the gut, which significantly lowers the amount of medicine that enters your body.
Gemfibrozil carries more major-labeled pairs than Colestipol
SPL source-record counts only. This page's band is minor · classes on file: Gemfibrozil (Fibrate); Colestipol (Bile Acid Sequestrant).
Gemfibrozil has 4 major-labeled pairs vs Colestipol's 0. This page itself is in the minor band, not the major band.
4 major · 8 moderate · 8 minor · 20 total
- Other minor peers for Gemfibrozil
- Colchicine
- Enzalutamide
- Metformin/Pioglitazone
- Montelukast
0 major · 1 moderate · 23 minor · 24 total
- Other minor peers for Colestipol
- Furosemide
- Aspirin
- Propranolol
- Warfarin
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.