Fluticasone/Salmeterol and Clarithromycin Interaction
Drug interaction information between Fluticasone/Salmeterol and Clarithromycin.
Fluticasone/Salmeterol and Clarithromycin have a documented moderate interaction in FDA labeling.
FDA drug labeling documents a moderate-severity interaction between Fluticasone/Salmeterol and Clarithromycin. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Clarithromycin blocks the enzyme that breaks down the ingredients in your inhaler. This can cause the medicine to build up in your body and increase the risk of side effects.
FDA Label Information
The use of strong CYP3A4 inhibitors (e.g., ritonavir, atazanavir, clarithromycin, indinavir, itraconazole, nefazodone, nelfinavir, saquinavir, ketoconazole, telithromycin) with ADVAIR DISKUS is not recommended because increased systemic corticosteroid and increased cardiovascular adverse effects may occur.
Fluticasone/Salmeterol Also Interacts With
- Ketoconazole moderate
- Itraconazole moderate
- Fluticasone minor
- Salmeterol minor
Clarithromycin Also Interacts With
- Quetiapine major
- Pioglitazone major
- Fluconazole major
- Cyclosporine major
- Lurasidone major
Frequently Asked Questions
What SPL severity band is on file for Fluticasone/Salmeterol + Clarithromycin?
Compiled FDA labeling labels this pair moderate. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Clarithromycin has 81 labeled pairs on file vs Fluticasone/Salmeterol's 5. In the moderate band specifically: Fluticasone/Salmeterol has 3 (also Ketoconazole, Itraconazole); Clarithromycin has 35 (also Omeprazole, Methylprednisolone, Sildenafil, Valproate).
What mechanism field is on file for Fluticasone/Salmeterol and Clarithromycin?
Clarithromycin blocks the enzyme that breaks down the ingredients in your inhaler. This can cause the medicine to build up in your body and increase the risk of side effects.
Clarithromycin carries more major-labeled pairs than Fluticasone/Salmeterol
SPL source-record counts only. This page's band is moderate · classes on file: Fluticasone/Salmeterol (Corticosteroid / Long-Acting Beta-2 Agonist Combination); Clarithromycin (Macrolide Antibiotic).
Clarithromycin has 16 major-labeled pairs vs Fluticasone/Salmeterol's 0. This page itself is in the moderate band, not the major band.
0 major · 3 moderate · 2 minor · 5 total
- Other moderate peers for Fluticasone/Salmeterol
- Ketoconazole
- Itraconazole
16 major · 35 moderate · 30 minor · 81 total
- Other moderate peers for Clarithromycin
- Omeprazole
- Methylprednisolone
- Sildenafil
- Valproate
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.