Fluticasone/Salmeterol and Fluticasone Interaction
Drug interaction information between Fluticasone/Salmeterol and Fluticasone.
Fluticasone/Salmeterol and Fluticasone have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Fluticasone/Salmeterol and Fluticasone. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Both of these products contain the same steroid medicine. Taking them together increases the amount of medicine in your body, which can lower your natural hormone levels.
FDA Label Information
( 7.4 ) 7.1 Inhibitors of Cytochrome P450 3A4 Fluticasone propionate and salmeterol, the individual components of ADVAIR DISKUS, are substrates of CYP3A4. Ritonavir Fluticasone Propionate: A drug interaction trial with fluticasone propionate aqueous nasal spray in healthy subjects has shown that ritonavir (a strong CYP3A4 inhibitor) can significantly increase plasma fluticasone propionate exposure, resulting in significantly reduced serum cortisol concentrations [see Clinical Pharmacology ( 12.3 )] . During postmarketing use, there have been reports of clinically significant drug...
Fluticasone/Salmeterol Also Interacts With
- Ketoconazole moderate
- Clarithromycin moderate
- Itraconazole moderate
- Salmeterol minor
Fluticasone Also Interacts With
- Darunavir moderate
- Nirmatrelvir/Ritonavir moderate
- Fluticasone/Umeclidinium/Vilanterol minor
- Fluticasone/Vilanterol minor
- Itraconazole minor
Frequently Asked Questions
What SPL severity band is on file for Fluticasone/Salmeterol + Fluticasone?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Fluticasone has 7 labeled pairs on file vs Fluticasone/Salmeterol's 5. In the minor band specifically: Fluticasone/Salmeterol has 2 (also Salmeterol); Fluticasone has 5 (also Fluticasone, Fluticasone/Vilanterol, Itraconazole, Salmeterol).
What mechanism field is on file for Fluticasone/Salmeterol and Fluticasone?
Both of these products contain the same steroid medicine. Taking them together increases the amount of medicine in your body, which can lower your natural hormone levels.
Fluticasone's labeled portfolio outnumbers Fluticasone/Salmeterol
SPL source-record counts only. This page's band is minor · classes on file: Fluticasone/Salmeterol (Corticosteroid / Long-Acting Beta-2 Agonist Combination); Fluticasone (Corticosteroid).
0 major · 3 moderate · 2 minor · 5 total
- Other minor peers for Fluticasone/Salmeterol
- Salmeterol
0 major · 2 moderate · 5 minor · 7 total
- Other minor peers for Fluticasone
- Fluticasone
- Fluticasone/Vilanterol
- Itraconazole
- Salmeterol
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.