Fluticasone/Salmeterol and Itraconazole Interaction
Drug interaction information between Fluticasone/Salmeterol and Itraconazole.
Fluticasone/Salmeterol and Itraconazole have a documented moderate interaction in FDA labeling.
FDA drug labeling documents a moderate-severity interaction between Fluticasone/Salmeterol and Itraconazole. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Itraconazole stops the body from breaking down the inhaler medicine, which can lead to higher levels in your blood and more side effects.
FDA Label Information
The use of strong CYP3A4 inhibitors (e.g., ritonavir, atazanavir, clarithromycin, indinavir, itraconazole, nefazodone, nelfinavir, saquinavir, ketoconazole, telithromycin) with ADVAIR DISKUS is not recommended because increased systemic corticosteroid and increased cardiovascular adverse effects may occur.
Fluticasone/Salmeterol Also Interacts With
- Ketoconazole moderate
- Clarithromycin moderate
- Fluticasone minor
- Salmeterol minor
Itraconazole Also Interacts With
- Isavuconazonium major
- Lurasidone major
- Pimozide major
- Methadone major
- Midazolam major
Frequently Asked Questions
What SPL severity band is on file for Fluticasone/Salmeterol + Itraconazole?
Compiled FDA labeling labels this pair moderate. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Itraconazole has 116 labeled pairs on file vs Fluticasone/Salmeterol's 5. In the moderate band specifically: Fluticasone/Salmeterol has 3 (also Ketoconazole, Clarithromycin); Itraconazole has 20 (also Tamsulosin, Rivaroxaban, Tenofovir Disoproxil, Glecaprevir/Pibrentasvir).
What mechanism field is on file for Fluticasone/Salmeterol and Itraconazole?
Itraconazole stops the body from breaking down the inhaler medicine, which can lead to higher levels in your blood and more side effects.
Itraconazole carries more major-labeled pairs than Fluticasone/Salmeterol
SPL source-record counts only. This page's band is moderate · classes on file: Fluticasone/Salmeterol (Corticosteroid / Long-Acting Beta-2 Agonist Combination); Itraconazole (Azole Antifungal).
Itraconazole has 19 major-labeled pairs vs Fluticasone/Salmeterol's 0. This page itself is in the moderate band, not the major band.
0 major · 3 moderate · 2 minor · 5 total
- Other moderate peers for Fluticasone/Salmeterol
- Ketoconazole
- Clarithromycin
19 major · 20 moderate · 77 minor · 116 total
- Other moderate peers for Itraconazole
- Tamsulosin
- Rivaroxaban
- Tenofovir Disoproxil
- Glecaprevir/Pibrentasvir
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.