What the FDA labels say about taking them together
Fluticasone/salmeterol and itraconazole
Fluticasone/salmeterol's FDA label of March 26, 2026 names itraconazole in its drug interactions section; the itraconazole labels PlainMeds reads (2) do not name fluticasone/salmeterol. The fluticasone/salmeterol label: “The use of strong CYP3A4 inhibitors with ADVAIR HFA is not recommended because increased systemic corticosteroid and increased cardiovascular adverse effects may occur.”
Check it at the source: the fluticasone/salmeterol FDA label on DailyMed (effective March 26, 2026, GlaxoSmithKline LLC); the itraconazole FDA label on DailyMed (effective July 13, 2026, Janssen Pharmaceuticals, Inc.).
What does the fluticasone/salmeterol label say about itraconazole?
Fluticasone/salmeterol label, drug interactionsThe use of strong CYP3A4 inhibitors (e.g., ritonavir, atazanavir, clarithromycin, indinavir, itraconazole, nefazodone, nelfinavir, saquinavir, ketoconazole, telithromycin) with ADVAIR DISKUS is not recommended because increased systemic corticosteroid and increased cardiovascular adverse effects may occur.
Fluticasone Propionate And Salmeterol label (A-S Medication Solutions, April 2, 2025), warnings and precautionsInteractions with Strong Cytochrome P450 3A4 Inhibitors The use of strong cytochrome P450 3A4 (CYP3A4) inhibitors (e.g., ritonavir, atazanavir, clarithromycin, indinavir, itraconazole, nefazodone, nelfinavir, saquinavir, ketoconazole, telithromycin) with Fluticasone Propionate/Salmeterol MDPI is not recommended because increased systemic corticosteroid and increased cardiovascular adverse effects may occur [see Drug Interactions ( 7.1 ) and Clinical Pharmacology ( 12.3 )].
Source: FDA drug label (Advair Hfa, NDA021254), GlaxoSmithKline LLC, effective May 23, 2024 (SPL set dfaca6f9-3277-47b2-319d-1377917cb54c), via openFDA
Source: FDA drug label (ADVAIR DISKUS), GlaxoSmithKline LLC, effective March 26, 2026 (SPL set 4eeb5f6a-593f-4a9e-9692-adefa2caf8fc), via openFDA; the full label on DailyMed
What does the itraconazole label say about fluticasone/salmeterol?
Itraconazole's label (effective July 13, 2026) and its 1 other brand-application label do not name fluticasone/salmeterol in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (SPORANOX), Janssen Pharmaceuticals, Inc., effective July 13, 2026 (SPL set a4d555fa-787c-40fb-bb7d-b0d4f7318fd0), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
These are the ingredient's own label sentences, repeated in a combination product's or a biosimilar's label. The ingredient pair sets them out with both labels side by side.
Both medicines on the record
| Fluticasone/salmeterol | Itraconazole | |
|---|---|---|
| Labeled for | Asthma, COPD | Fungal infections |
| Boxed warning | No | Yes |
| Pharmacy cost (NADAC) | $1.07 per unit 100-50 | $0.910 per capsule 100 mg capsule |
| Shortage now | A presentation being discontinued | A presentation being discontinued |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once