Fluticasone/Salmeterol and Ketoconazole Interaction
Drug interaction information between Fluticasone/Salmeterol and Ketoconazole.
Fluticasone/Salmeterol and Ketoconazole have a documented moderate interaction in FDA labeling.
FDA drug labeling documents a moderate-severity interaction between Fluticasone/Salmeterol and Ketoconazole. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Ketoconazole stops your body from clearing the medicine in the inhaler. This can lead to higher levels of the steroid in your body and may cause heart-related side effects.
FDA Label Information
• Strong cytochrome P450 3A4 inhibitors (e.g., ritonavir, ketoconazole): Use not recommended. The use of strong CYP3A4 inhibitors (e.g., ritonavir, atazanavir, clarithromycin, indinavir, itraconazole, nefazodone, nelfinavir, saquinavir, ketoconazole, telithromycin) with ADVAIR DISKUS is not recommended because increased systemic corticosteroid and increased cardiovascular adverse effects may occur. Ketoconazole Fluticasone Propionate: Coadministration of orally inhaled fluticasone propionate (1,000 mcg) and ketoconazole (200 mg once daily) resulted in a 1.9-fold increase in plasma...
Fluticasone/Salmeterol Also Interacts With
- Clarithromycin moderate
- Itraconazole moderate
- Fluticasone minor
- Salmeterol minor
Ketoconazole Also Interacts With
- Alfuzosin major
- Dronedarone major
- Ranolazine major
- Saxagliptin major
- Sildenafil major
Frequently Asked Questions
What SPL severity band is on file for Fluticasone/Salmeterol + Ketoconazole?
Compiled FDA labeling labels this pair moderate. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Ketoconazole has 113 labeled pairs on file vs Fluticasone/Salmeterol's 5. In the moderate band specifically: Fluticasone/Salmeterol has 3 (also Clarithromycin, Itraconazole); Ketoconazole has 22 (also Alprazolam, Aprepitant, Budesonide/Formoterol, Dexamethasone).
What mechanism field is on file for Fluticasone/Salmeterol and Ketoconazole?
Ketoconazole stops your body from clearing the medicine in the inhaler. This can lead to higher levels of the steroid in your body and may cause heart-related side effects.
Ketoconazole carries more major-labeled pairs than Fluticasone/Salmeterol
SPL source-record counts only. This page's band is moderate · classes on file: Fluticasone/Salmeterol (Corticosteroid / Long-Acting Beta-2 Agonist Combination); Ketoconazole (Azole Antifungal).
Ketoconazole has 6 major-labeled pairs vs Fluticasone/Salmeterol's 0. This page itself is in the moderate band, not the major band.
0 major · 3 moderate · 2 minor · 5 total
- Other moderate peers for Fluticasone/Salmeterol
- Clarithromycin
- Itraconazole
6 major · 22 moderate · 85 minor · 113 total
- Other moderate peers for Ketoconazole
- Alprazolam
- Aprepitant
- Budesonide/Formoterol
- Dexamethasone
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.