Fluticasone/Salmeterol and Salmeterol Interaction
Drug interaction information between Fluticasone/Salmeterol and Salmeterol.
Fluticasone/Salmeterol and Salmeterol have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Fluticasone/Salmeterol and Salmeterol. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
These two products contain the same active ingredient. Taking both at once can lead to an overdose, which may cause heart or blood pressure problems.
FDA Label Information
May potentiate effect of salmeterol on vascular system. ( 7.4 ) 7.1 Inhibitors of Cytochrome P450 3A4 Fluticasone propionate and salmeterol, the individual components of ADVAIR DISKUS, are substrates of CYP3A4. Salmeterol: In a drug interaction trial in 20 healthy subjects, coadministration of inhaled salmeterol (50 mcg twice daily) and oral ketoconazole (400 mg once daily) for 7 days resulted in greater systemic exposure to salmeterol (AUC increased 16-fold and C max increased 1.4-fold).
Fluticasone/Salmeterol Also Interacts With
- Ketoconazole moderate
- Clarithromycin moderate
- Itraconazole moderate
- Fluticasone minor
Salmeterol Also Interacts With
- Ketoconazole moderate
- Clarithromycin moderate
- Itraconazole moderate
- Nirmatrelvir/Ritonavir moderate
- Fluticasone minor
Frequently Asked Questions
What SPL severity band is on file for Fluticasone/Salmeterol + Salmeterol?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Salmeterol has 7 labeled pairs on file vs Fluticasone/Salmeterol's 5. In the minor band specifically: Fluticasone/Salmeterol has 2 (also Fluticasone); Salmeterol has 3 (also Fluticasone, Darunavir).
What mechanism field is on file for Fluticasone/Salmeterol and Salmeterol?
These two products contain the same active ingredient. Taking both at once can lead to an overdose, which may cause heart or blood pressure problems.
Salmeterol's labeled portfolio outnumbers Fluticasone/Salmeterol
SPL source-record counts only. This page's band is minor · classes on file: Fluticasone/Salmeterol (Corticosteroid / Long-Acting Beta-2 Agonist Combination); Salmeterol (Long-Acting Beta-2 Agonist (LABA)).
0 major · 3 moderate · 2 minor · 5 total
- Other minor peers for Fluticasone/Salmeterol
- Fluticasone
0 major · 4 moderate · 3 minor · 7 total
- Other minor peers for Salmeterol
- Fluticasone
- Darunavir
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.