Fluticasone and Itraconazole Interaction
Drug interaction information between Fluticasone and Itraconazole.
Fluticasone and Itraconazole have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Fluticasone and Itraconazole. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Itraconazole can prevent your body from clearing fluticasone, which may increase the risk of steroid-related side effects.
FDA Label Information
Budesonide (inhalation) a Budesonide (non-inhalation) Ciclesonide (inhalation) Cyclosporine (IV) a Cyclosporine (non-IV) Dexamethasone a Fluticasone (inhalation) a Fluticasone (nasal)Methylprednisolone a Tacrolimus (IV) a Tacrolimus (oral) Monitor for adverse reactions.
Fluticasone Also Interacts With
- Darunavir moderate
- Nirmatrelvir/Ritonavir moderate
- Fluticasone/Salmeterol minor
- Fluticasone/Umeclidinium/Vilanterol minor
- Fluticasone/Vilanterol minor
Itraconazole Also Interacts With
- Isavuconazonium major
- Lurasidone major
- Pimozide major
- Methadone major
- Midazolam major
Frequently Asked Questions
What SPL severity band is on file for Fluticasone + Itraconazole?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Itraconazole has 116 labeled pairs on file vs Fluticasone's 7. In the minor band specifically: Fluticasone has 5 (also Fluticasone/Salmeterol, Fluticasone, Fluticasone/Vilanterol, Salmeterol); Itraconazole has 77 (also Meloxicam, Buspirone, Oxycodone, Venlafaxine).
What mechanism field is on file for Fluticasone and Itraconazole?
Itraconazole can prevent your body from clearing fluticasone, which may increase the risk of steroid-related side effects.
Itraconazole carries more major-labeled pairs than Fluticasone
SPL source-record counts only. This page's band is minor · classes on file: Fluticasone (Corticosteroid); Itraconazole (Azole Antifungal).
Itraconazole has 19 major-labeled pairs vs Fluticasone's 0. This page itself is in the minor band, not the major band.
0 major · 2 moderate · 5 minor · 7 total
- Other minor peers for Fluticasone
- Fluticasone/Salmeterol
- Fluticasone
- Fluticasone/Vilanterol
- Salmeterol
19 major · 20 moderate · 77 minor · 116 total
- Other minor peers for Itraconazole
- Meloxicam
- Buspirone
- Oxycodone
- Venlafaxine
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.