Fluticasone and Darunavir Interaction
Drug interaction information between Fluticasone and Darunavir.
Fluticasone and Darunavir have a documented moderate interaction in FDA labeling.
FDA drug labeling documents a moderate-severity interaction between Fluticasone and Darunavir. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Darunavir blocks the body from breaking down fluticasone, which can lead to very high steroid levels in your blood. This can cause serious hormone problems like Cushing's syndrome.
FDA Label Information
betamethasone budesonide ciclesonide fluticasone methylprednisolone mometasone triamcinolone ↑ corticosteroids Co-administration with corticosteroids (all routes of administration) of which exposures are significantly increased by strong CYP3A inhibitors can increase the risk for Cushing's syndrome and adrenal suppression.
Fluticasone Also Interacts With
- Nirmatrelvir/Ritonavir moderate
- Fluticasone/Salmeterol minor
- Fluticasone/Umeclidinium/Vilanterol minor
- Fluticasone/Vilanterol minor
- Itraconazole minor
Darunavir Also Interacts With
- Lovastatin major
- Sildenafil major
- Lurasidone major
- Pimozide major
- Midazolam major
Frequently Asked Questions
What SPL severity band is on file for Fluticasone + Darunavir?
Compiled FDA labeling labels this pair moderate. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Darunavir has 101 labeled pairs on file vs Fluticasone's 7. In the moderate band specifically: Fluticasone has 2 (also Nirmatrelvir/Ritonavir); Darunavir has 16 (also Omeprazole, Apixaban, Clopidogrel, Quetiapine).
What mechanism field is on file for Fluticasone and Darunavir?
Darunavir blocks the body from breaking down fluticasone, which can lead to very high steroid levels in your blood. This can cause serious hormone problems like Cushing's syndrome.
Darunavir carries more major-labeled pairs than Fluticasone
SPL source-record counts only. This page's band is moderate · classes on file: Fluticasone (Corticosteroid); Darunavir (HIV Protease Inhibitor).
Darunavir has 15 major-labeled pairs vs Fluticasone's 0. This page itself is in the moderate band, not the major band.
0 major · 2 moderate · 5 minor · 7 total
- Other moderate peers for Fluticasone
- Nirmatrelvir/Ritonavir
15 major · 16 moderate · 70 minor · 101 total
- Other moderate peers for Darunavir
- Omeprazole
- Apixaban
- Clopidogrel
- Quetiapine
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.