Fluticasone and Fluticasone Interaction
Drug interaction information between Fluticasone and Fluticasone.
Fluticasone and Fluticasone have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Fluticasone and Fluticasone. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Both of these medications contain the same steroid ingredient. Taking them together increases the total amount of medicine in your body, which can lead to more side effects.
FDA Label Information
( 7.5 ) 7.1 Inhibitors of Cytochrome P450 3A4 Fluticasone furoate and vilanterol are substrates of CYP3A4. Concomitant administration of the strong CYP3A4 inhibitor ketoconazole increases the systemic exposure to fluticasone furoate and vilanterol.
Fluticasone Also Interacts With
- Darunavir moderate
- Nirmatrelvir/Ritonavir moderate
- Fluticasone/Salmeterol minor
- Fluticasone/Vilanterol minor
- Itraconazole minor
Frequently Asked Questions
What SPL severity band is on file for Fluticasone + Fluticasone/Umeclidinium/Vilanterol?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Fluticasone has 7 labeled pairs on file vs Fluticasone's 2. In the minor band specifically: Fluticasone has 5 (also Fluticasone/Salmeterol, Fluticasone/Vilanterol, Itraconazole, Salmeterol); Fluticasone has 1.
What mechanism field is on file for Fluticasone and Fluticasone/Umeclidinium/Vilanterol?
Both of these medications contain the same steroid ingredient. Taking them together increases the total amount of medicine in your body, which can lead to more side effects.
Fluticasone's labeled portfolio outnumbers Fluticasone
SPL source-record counts only. This page's band is minor · classes on file: Fluticasone (Corticosteroid); Fluticasone (Triple Therapy (ICS/LAMA/LABA)).
0 major · 2 moderate · 5 minor · 7 total
- Other minor peers for Fluticasone
- Fluticasone/Salmeterol
- Fluticasone/Vilanterol
- Itraconazole
- Salmeterol
0 major · 1 moderate · 1 minor · 2 total
Fluticasone has no other minor-band peer in this dataset besides Fluticasone.
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.