Fluticasone and Fluticasone/Vilanterol Interaction
Drug interaction information between Fluticasone and Fluticasone/Vilanterol.
Fluticasone and Fluticasone/Vilanterol have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Fluticasone and Fluticasone/Vilanterol. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
These two medications contain the same active steroid. Using them at the same time can cause the drug levels to build up too high in your system.
FDA Label Information
( 7.4 ) 7.1 Inhibitors of Cytochrome P450 3A4 Fluticasone furoate and vilanterol are both substrates of CYP3A4. Concomitant administration of the strong CYP3A4 inhibitor ketoconazole increases the systemic exposure to fluticasone furoate and vilanterol.
Fluticasone Also Interacts With
- Darunavir moderate
- Nirmatrelvir/Ritonavir moderate
- Fluticasone/Salmeterol minor
- Fluticasone/Umeclidinium/Vilanterol minor
- Itraconazole minor
Fluticasone/Vilanterol Also Interacts With
- Ketoconazole moderate
Frequently Asked Questions
What SPL severity band is on file for Fluticasone + Fluticasone/Vilanterol?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Fluticasone has 7 labeled pairs on file vs Fluticasone/Vilanterol's 2. In the minor band specifically: Fluticasone has 5 (also Fluticasone/Salmeterol, Fluticasone, Itraconazole, Salmeterol); Fluticasone/Vilanterol has 1.
What mechanism field is on file for Fluticasone and Fluticasone/Vilanterol?
These two medications contain the same active steroid. Using them at the same time can cause the drug levels to build up too high in your system.
Fluticasone's labeled portfolio outnumbers Fluticasone/Vilanterol
SPL source-record counts only. This page's band is minor · classes on file: Fluticasone (Corticosteroid); Fluticasone/Vilanterol (Corticosteroid / Long-Acting Beta-2 Agonist Combination).
0 major · 2 moderate · 5 minor · 7 total
- Other minor peers for Fluticasone
- Fluticasone/Salmeterol
- Fluticasone
- Itraconazole
- Salmeterol
0 major · 1 moderate · 1 minor · 2 total
Fluticasone/Vilanterol has no other minor-band peer in this dataset besides Fluticasone.
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.