fluticasone vs itraconazole
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Side-by-side comparison of fluticasone and itraconazole. Data from FDA drug databases (Orange Book, NDC Directory, recalls, shortages) covering 20,000+ approved drugs, plus CMS pricing; see our methodology.
minor Known Drug Interaction
Budesonide (inhalation) a Budesonide (non-inhalation) Ciclesonide (inhalation) Cyclosporine (IV) a Cyclosporine (non-IV) Dexamethasone a Fluticasone (inhalation) a Fluticasone (nasal)Methylprednisolone a Tacrolimus (IV) a Tacrolimus (oral) Monitor for adverse reactions.
Flonase, Flovent
Sporanox
Fluticasone is a steroid medicine that helps reduce inflammation in your nose. It can help relieve allergy symptoms.
Itraconazole capsules are an antifungal medicine. They treat fungal infections in your body.
Fluticasone temporarily relieves symptoms of hay fever or other upper respiratory allergies. These symptoms include a stuffy nose, itchy and watery eyes, itchy nose, runny nose, and sneezing. It can help you breathe easier and feel more comfortable when you have allergies.
Itraconazole treats fungal infections like blastomycosis, histoplasmosis, and aspergillosis. It can help both people with healthy immune systems and those with weakened immune systems. It also treats onychomycosis, a fungal infection of the toenails or fingernails.
Fluticasone is a corticosteroid. It works by reducing inflammation in the nasal passages. This helps to relieve allergy symptoms.
Itraconazole stops fungi from growing. It does this by interfering with the production of a substance fungi need to build their cell membranes. This eventually kills the fungus and clears the infection.
- • Headache
- • Fatigue
- • Nausea
- • Rash
- • Headache
- Headache 6,061
- Tiredness 5,935
- Difficulty breathing 5,830
- Feeling sick to your stomach 5,209
- Pain 4,528
- Drug Interaction 1,118
- Pyrexia 568
- Dyspnoea 474
- Pneumonia 461
- Nausea 445
Children 4 to 11 years of age: The growth rate of some children may be slower while using this product. Children should use it for the shortest time needed to relieve symptoms. Talk to your child’s doctor if they need to use the spray for longer than two months a year.
Itraconazole can cause congestive heart failure. You should not take this medicine if you have heart problems. Itraconazole can also interact with many other medicines. Some of these interactions can be dangerous or even fatal. Check with your doctor about all the medicines you take.
It is not known if fluticasone will harm an unborn baby. Talk to your doctor if you are pregnant or plan to become pregnant. It is also not known if fluticasone passes into breast milk. Talk to your doctor if you are breastfeeding.
You should not take itraconazole if you are pregnant or plan to become pregnant. It can harm your unborn baby. Talk to your doctor about safe alternatives.
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How to Read This fluticasone vs itraconazole Comparison
fluticasone is classified in the Corticosteroid drug class, while itraconazole sits within the Azole Antifungal class. Drugs from different classes work through distinct mechanisms, so a head-to-head comparison illustrates trade-offs rather than equivalence. Both drugs are split between OTC and prescription status, which affects access and supervision.
Adverse event totals above are pulled from the FDA's Adverse Event Reporting System (FAERS). For these top-ranked reactions alone, fluticasone has 27,563 submissions while itraconazole has 3,066. Those figures reflect cumulative reporting volume, not per-patient risk, so older, widely dispensed drugs typically look worse on count alone. These two drugs have a known minor interaction flagged in FDA labeling, attributed to itraconazole can prevent your body from clearing fluticasone, which may increase the risk of steroid-related side effects.. Serious warnings, pregnancy guidance, and contraindications can differ even when indications overlap.
A table cannot represent individual circumstances. Data here is sourced from FDA Structured Product Labels (SPL) and FAERS, both of which update as manufacturers and clinicians submit new information. This registry does not provide medical, treatment, substitution, or medication-change directions for fluticasone or itraconazole.
Registry boundary: This comparison displays source-record fields and does not provide individualized medical direction.