Febuxostat and Naproxen Interaction
Drug interaction information between Febuxostat and Naproxen.
Febuxostat and Naproxen have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Febuxostat and Naproxen. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Research shows that these two medications do not significantly change how the other works in the body.
FDA Label Information
7.3 In Vivo Drug Interaction Studies Based on drug interaction studies in healthy patients, febuxostat does not have clinically significant interactions with colchicine, naproxen, indomethacin, hydrochlorothiazide, warfarin or desipramine [see Clinical Pharmacology (12.3) ].
Febuxostat Also Interacts With
- Rosuvastatin major
- Rosuvastatin/Ezetimibe major
- Theophylline moderate
- Hydrochlorothiazide minor
- Warfarin minor
Naproxen Also Interacts With
- Methotrexate moderate
- Magnesium Oxide moderate
- Diflunisal moderate
- Sucralfate moderate
- Cholestyramine moderate
Frequently Asked Questions
What SPL severity band is on file for Febuxostat + Naproxen?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Naproxen has 23 labeled pairs on file vs Febuxostat's 9. In the minor band specifically: Febuxostat has 6 (also Hydrochlorothiazide, Warfarin, Desipramine, Indomethacin); Naproxen has 18 (also Meloxicam, Furosemide, Aspirin, Propranolol).
What mechanism field is on file for Febuxostat and Naproxen?
Research shows that these two medications do not significantly change how the other works in the body.
Febuxostat carries more major-labeled pairs than Naproxen
SPL source-record counts only. This page's band is minor · classes on file: Febuxostat (Xanthine Oxidase Inhibitor); Naproxen (Nonsteroidal Anti-Inflammatory Drug (NSAID)).
Febuxostat has 2 major-labeled pairs vs Naproxen's 0. This page itself is in the minor band, not the major band.
2 major · 1 moderate · 6 minor · 9 total
- Other minor peers for Febuxostat
- Hydrochlorothiazide
- Warfarin
- Desipramine
- Indomethacin
0 major · 5 moderate · 18 minor · 23 total
- Other minor peers for Naproxen
- Meloxicam
- Furosemide
- Aspirin
- Propranolol
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.