Febuxostat and Rosuvastatin Interaction
Drug interaction information between Febuxostat and Rosuvastatin.
Febuxostat and Rosuvastatin have a documented major interaction in FDA labeling.
FDA drug labeling documents a major-severity interaction between Febuxostat and Rosuvastatin. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Febuxostat slows down how your body gets rid of rosuvastatin, causing the medicine to build up in your blood. This increase can make side effects more likely.
FDA Label Information
Febuxostat Clinical Impact: Febuxostat increased rosuvastatin exposure more than 1.9-fold. Intervention: In patients taking febuxostat, do not exceed a dose of rosuvastatin 20 mg once daily.
Febuxostat Also Interacts With
- Rosuvastatin/Ezetimibe major
- Theophylline moderate
- Hydrochlorothiazide minor
- Naproxen minor
- Warfarin minor
Rosuvastatin Also Interacts With
- Sofosbuvir/Velpatasvir major
- Glecaprevir/Pibrentasvir major
- Cyclosporine moderate
- Ledipasvir/Sofosbuvir moderate
- Colchicine moderate
Frequently Asked Questions
What SPL severity band is on file for Febuxostat + Rosuvastatin?
Compiled FDA labeling labels this pair major. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Rosuvastatin has 21 labeled pairs on file vs Febuxostat's 9. In the major band specifically: Febuxostat has 2 (also Rosuvastatin/Ezetimibe); Rosuvastatin has 3 (also Sofosbuvir/Velpatasvir, Glecaprevir/Pibrentasvir).
What mechanism field is on file for Febuxostat and Rosuvastatin?
Febuxostat slows down how your body gets rid of rosuvastatin, causing the medicine to build up in your blood. This increase can make side effects more likely.
Rosuvastatin carries more major-labeled pairs than Febuxostat
SPL source-record counts only. This page's band is major · classes on file: Febuxostat (Xanthine Oxidase Inhibitor); Rosuvastatin (HMG-CoA Reductase Inhibitor (Statin)).
Rosuvastatin has 3 major-labeled pairs vs Febuxostat's 2.
2 major · 1 moderate · 6 minor · 9 total
- Other major peers for Febuxostat
- Rosuvastatin/Ezetimibe
3 major · 8 moderate · 10 minor · 21 total
- Other major peers for Rosuvastatin
- Sofosbuvir/Velpatasvir
- Glecaprevir/Pibrentasvir
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.