Febuxostat and Hydrochlorothiazide Interaction
Drug interaction information between Febuxostat and Hydrochlorothiazide.
Febuxostat and Hydrochlorothiazide have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Febuxostat and Hydrochlorothiazide. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
These drugs do not have a meaningful effect on each other when taken at the same time.
FDA Label Information
7.3 In Vivo Drug Interaction Studies Based on drug interaction studies in healthy patients, febuxostat does not have clinically significant interactions with colchicine, naproxen, indomethacin, hydrochlorothiazide, warfarin or desipramine [see Clinical Pharmacology (12.3) ].
Febuxostat Also Interacts With
- Rosuvastatin major
- Rosuvastatin/Ezetimibe major
- Theophylline moderate
- Naproxen minor
- Warfarin minor
Hydrochlorothiazide Also Interacts With
- Aliskiren major
- Hydrochlorothiazide/Triamterene major
- Lisinopril major
- Olmesartan moderate
- Losartan minor
Frequently Asked Questions
What SPL severity band is on file for Febuxostat + Hydrochlorothiazide?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Hydrochlorothiazide has 31 labeled pairs on file vs Febuxostat's 9. In the minor band specifically: Febuxostat has 6 (also Naproxen, Warfarin, Desipramine, Indomethacin); Hydrochlorothiazide has 27 (also Losartan, Spironolactone, Propranolol, Lithium).
What mechanism field is on file for Febuxostat and Hydrochlorothiazide?
These drugs do not have a meaningful effect on each other when taken at the same time.
Hydrochlorothiazide carries more major-labeled pairs than Febuxostat
SPL source-record counts only. This page's band is minor · classes on file: Febuxostat (Xanthine Oxidase Inhibitor); Hydrochlorothiazide (Thiazide Diuretic).
Hydrochlorothiazide has 3 major-labeled pairs vs Febuxostat's 2. This page itself is in the minor band, not the major band.
2 major · 1 moderate · 6 minor · 9 total
- Other minor peers for Febuxostat
- Naproxen
- Warfarin
- Desipramine
- Indomethacin
3 major · 1 moderate · 27 minor · 31 total
- Other minor peers for Hydrochlorothiazide
- Losartan
- Spironolactone
- Propranolol
- Lithium
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.