Febuxostat and Desipramine Interaction
Drug interaction information between Febuxostat and Desipramine.
Febuxostat and Desipramine have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Febuxostat and Desipramine. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
These two drugs do not have a meaningful effect on how the body processes each other.
FDA Label Information
7.3 In Vivo Drug Interaction Studies Based on drug interaction studies in healthy patients, febuxostat does not have clinically significant interactions with colchicine, naproxen, indomethacin, hydrochlorothiazide, warfarin or desipramine [see Clinical Pharmacology (12.3) ].
Febuxostat Also Interacts With
- Rosuvastatin major
- Rosuvastatin/Ezetimibe major
- Theophylline moderate
- Hydrochlorothiazide minor
- Naproxen minor
Desipramine Also Interacts With
- Atomoxetine minor
- Bupropion minor
- Darunavir minor
- Desvenlafaxine minor
- Dopamine minor
Frequently Asked Questions
What SPL severity band is on file for Febuxostat + Desipramine?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Desipramine has 18 labeled pairs on file vs Febuxostat's 9. In the minor band specifically: Febuxostat has 6 (also Hydrochlorothiazide, Naproxen, Warfarin, Indomethacin); Desipramine has 18 (also Atomoxetine, Bupropion, Darunavir, Desvenlafaxine).
What mechanism field is on file for Febuxostat and Desipramine?
These two drugs do not have a meaningful effect on how the body processes each other.
Febuxostat carries more major-labeled pairs than Desipramine
SPL source-record counts only. This page's band is minor · classes on file: Febuxostat (Xanthine Oxidase Inhibitor); Desipramine (Tricyclic Antidepressant (TCA)).
Febuxostat has 2 major-labeled pairs vs Desipramine's 0. This page itself is in the minor band, not the major band.
2 major · 1 moderate · 6 minor · 9 total
- Other minor peers for Febuxostat
- Hydrochlorothiazide
- Naproxen
- Warfarin
- Indomethacin
0 major · 0 moderate · 18 minor · 18 total
- Other minor peers for Desipramine
- Atomoxetine
- Bupropion
- Darunavir
- Desvenlafaxine
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.