Febuxostat and Warfarin Interaction
Drug interaction information between Febuxostat and Warfarin.
Febuxostat and Warfarin have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Febuxostat and Warfarin. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
These drugs do not interact in a way that causes a significant change in how they work.
FDA Label Information
7.3 In Vivo Drug Interaction Studies Based on drug interaction studies in healthy patients, febuxostat does not have clinically significant interactions with colchicine, naproxen, indomethacin, hydrochlorothiazide, warfarin or desipramine [see Clinical Pharmacology (12.3) ].
Febuxostat Also Interacts With
- Rosuvastatin major
- Rosuvastatin/Ezetimibe major
- Theophylline moderate
- Hydrochlorothiazide minor
- Naproxen minor
Warfarin Also Interacts With
- Fluoxetine major
- Tamoxifen major
- Ibuprofen moderate
- Aspirin moderate
- Diclofenac moderate
Frequently Asked Questions
What SPL severity band is on file for Febuxostat + Warfarin?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Warfarin has 163 labeled pairs on file vs Febuxostat's 9. In the minor band specifically: Febuxostat has 6 (also Hydrochlorothiazide, Naproxen, Desipramine, Indomethacin); Warfarin has 133 (also Atorvastatin, Amlodipine, Omeprazole, Famotidine).
What mechanism field is on file for Febuxostat and Warfarin?
These drugs do not interact in a way that causes a significant change in how they work.
Warfarin's labeled portfolio outnumbers Febuxostat
SPL source-record counts only. This page's band is minor · classes on file: Febuxostat (Xanthine Oxidase Inhibitor); Warfarin (Vitamin K Antagonist (Anticoagulant)).
2 major · 1 moderate · 6 minor · 9 total
- Other minor peers for Febuxostat
- Hydrochlorothiazide
- Naproxen
- Desipramine
- Indomethacin
2 major · 28 moderate · 133 minor · 163 total
- Other minor peers for Warfarin
- Atorvastatin
- Amlodipine
- Omeprazole
- Famotidine
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.