What the FDA labels say about taking them together
Febuxostat and indomethacin
Febuxostat's FDA label of December 24, 2025 names indomethacin in its drug interactions section; the indomethacin labels PlainMeds reads (4) do not name febuxostat.
Check it at the source: the febuxostat FDA label on DailyMed (effective December 24, 2025, Takeda Pharmaceuticals America, Inc.); the indomethacin FDA label on DailyMed (effective December 19, 2025, Glenmark Pharmaceuticals Inc., USA).
What does the febuxostat label say about indomethacin?
Febuxostat label, drug interactionsBased on drug interaction studies in healthy patients, ULORIC does not have clinically significant interactions with colchicine, naproxen, indomethacin, hydrochlorothiazide, warfarin or desipramine [see Clinical Pharmacology (12.3) ].
Source: FDA drug label (ULORIC), Takeda Pharmaceuticals America, Inc., effective December 24, 2025 (SPL set 54de10ef-fe5f-4930-b91d-6bbb04c664bd), via openFDA; the full label on DailyMed
What does the indomethacin label say about febuxostat?
Indomethacin's label (effective December 19, 2025) and its 3 other brand-application labels do not name febuxostat in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Indomethacin), Glenmark Pharmaceuticals Inc., USA, effective December 19, 2025 (SPL set f7ed39e2-5431-4e47-935c-c7441d058f94), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Febuxostat | Indomethacin | |
|---|---|---|
| Labeled for | Gout | Rheumatoid arthritis, Osteoarthritis |
| Boxed warning | Yes | Yes |
| Pharmacy cost (NADAC) | $0.191 per tablet 40 mg tablet | $0.210 per capsule 75 mg capsule |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once