Desipramine and Atomoxetine Interaction
Drug interaction information between Desipramine and Atomoxetine.
Desipramine and Atomoxetine have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Desipramine and Atomoxetine. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Atomoxetine does not change how the body processes desipramine, even though both drugs use the same liver enzyme.
FDA Label Information
CYP2D6 Substrate (e.g., Desipramine) — Coadministration of atomoxetine (40 or 60 mg BID for 13 days) with desipramine, a model compound for CYP2D6 metabolized drugs (single dose of 50 mg), did not alter the pharmacokinetics of desipramine.
Desipramine Also Interacts With
- Bupropion minor
- Darunavir minor
- Desvenlafaxine minor
- Dopamine minor
- Duloxetine minor
Atomoxetine Also Interacts With
- Albuterol moderate
- Omeprazole minor
- Fluoxetine minor
- Methylphenidate minor
- Warfarin minor
Frequently Asked Questions
What SPL severity band is on file for Desipramine + Atomoxetine?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Desipramine has 18 labeled pairs on file vs Atomoxetine's 15. In the minor band specifically: Desipramine has 18 (also Bupropion, Darunavir, Desvenlafaxine, Dopamine); Atomoxetine has 14 (also Omeprazole, Fluoxetine, Methylphenidate, Warfarin).
What mechanism field is on file for Desipramine and Atomoxetine?
Atomoxetine does not change how the body processes desipramine, even though both drugs use the same liver enzyme.
Desipramine's labeled portfolio outnumbers Atomoxetine
SPL source-record counts only. This page's band is minor · classes on file: Desipramine (Tricyclic Antidepressant (TCA)); Atomoxetine (Selective Norepinephrine Reuptake Inhibitor).
0 major · 0 moderate · 18 minor · 18 total
- Other minor peers for Desipramine
- Bupropion
- Darunavir
- Desvenlafaxine
- Dopamine
0 major · 1 moderate · 14 minor · 15 total
- Other minor peers for Atomoxetine
- Omeprazole
- Fluoxetine
- Methylphenidate
- Warfarin
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.