Desipramine and Dopamine Interaction
Drug interaction information between Desipramine and Dopamine.
Desipramine and Dopamine have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Desipramine and Dopamine. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
This drug makes your body more sensitive to dopamine's effects on the heart and blood pressure. It prevents the body from soaking up chemicals that dopamine works with, making the effect stronger.
FDA Label Information
Examples: amitriptyline, desipramine, doxepin, imipramine, nortriptyline.
Desipramine Also Interacts With
- Atomoxetine minor
- Bupropion minor
- Darunavir minor
- Desvenlafaxine minor
- Duloxetine minor
Dopamine Also Interacts With
- Carbidopa/Levodopa moderate
- Deutetrabenazine moderate
- Digoxin moderate
- Tetrabenazine moderate
- Tranylcypromine moderate
Frequently Asked Questions
What SPL severity band is on file for Desipramine + Dopamine?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Dopamine has 28 labeled pairs on file vs Desipramine's 18. In the minor band specifically: Desipramine has 18 (also Atomoxetine, Bupropion, Darunavir, Desvenlafaxine); Dopamine has 23 (also Amitriptyline, Doxepin, Linezolid, Nortriptyline).
What mechanism field is on file for Desipramine and Dopamine?
This drug makes your body more sensitive to dopamine's effects on the heart and blood pressure. It prevents the body from soaking up chemicals that dopamine works with, making the effect stronger.
Dopamine's labeled portfolio outnumbers Desipramine
SPL source-record counts only. This page's band is minor · classes on file: Desipramine (Tricyclic Antidepressant (TCA)); Dopamine (Inotropic / Vasopressor).
0 major · 0 moderate · 18 minor · 18 total
- Other minor peers for Desipramine
- Atomoxetine
- Bupropion
- Darunavir
- Desvenlafaxine
0 major · 5 moderate · 23 minor · 28 total
- Other minor peers for Dopamine
- Amitriptyline
- Doxepin
- Linezolid
- Nortriptyline
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.