Desipramine and Desvenlafaxine Interaction
Drug interaction information between Desipramine and Desvenlafaxine.
Desipramine and Desvenlafaxine have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Desipramine and Desvenlafaxine. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Desvenlafaxine may interfere with the way your body breaks down desipramine, potentially leading to higher levels of the medication in your blood.
FDA Label Information
Examples desipramine, atomoxetine, dextromethorphan, metoprolol, nebivolol, perphenazine, tolterodine 7.2 Drugs Having No Clinically Important Interactions with PRISTIQ Based on pharmacokinetic studies, no dosage adjustment is required for drugs that are mainly metabolized by CYP3A4 (e.g., midazolam), or for drugs that are metabolized by both CYP2D6 and CYP3A4 (e.g., tamoxifen, aripiprazole), when administered concomitantly with PRISTIQ [see Clinical Pharmacology (12.3) ].
Desipramine Also Interacts With
- Atomoxetine minor
- Bupropion minor
- Darunavir minor
- Dopamine minor
- Duloxetine minor
Desvenlafaxine Also Interacts With
- Aspirin moderate
- Linezolid moderate
- Phenelzine moderate
- Tranylcypromine moderate
- Selegiline moderate
Frequently Asked Questions
What SPL severity band is on file for Desipramine + Desvenlafaxine?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Desvenlafaxine has 19 labeled pairs on file vs Desipramine's 18. In the minor band specifically: Desipramine has 18 (also Atomoxetine, Bupropion, Darunavir, Dopamine); Desvenlafaxine has 13 (also Metoprolol, Buspirone, Aripiprazole, Atomoxetine).
What mechanism field is on file for Desipramine and Desvenlafaxine?
Desvenlafaxine may interfere with the way your body breaks down desipramine, potentially leading to higher levels of the medication in your blood.
Desvenlafaxine's labeled portfolio outnumbers Desipramine
SPL source-record counts only. This page's band is minor · classes on file: Desipramine (Tricyclic Antidepressant (TCA)); Desvenlafaxine (Serotonin-Norepinephrine Reuptake Inhibitor (SNRI)).
0 major · 0 moderate · 18 minor · 18 total
- Other minor peers for Desipramine
- Atomoxetine
- Bupropion
- Darunavir
- Dopamine
0 major · 6 moderate · 13 minor · 19 total
- Other minor peers for Desvenlafaxine
- Metoprolol
- Buspirone
- Aripiprazole
- Atomoxetine
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.