Desipramine and Bupropion Interaction
Drug interaction information between Desipramine and Bupropion.
Desipramine and Bupropion have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Desipramine and Bupropion. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Bupropion interferes with the way your body breaks down desipramine, causing the drug to stay in your system longer.
FDA Label Information
( 7.1 ) Drugs metabolized by CYP2D6: Bupropion inhibits CYP2D6 and can increase concentrations of: antidepressants (e.g., venlafaxine, nortriptyline, imipramine, desipramine, paroxetine, fluoxetine, sertraline), antipsychotics (e.g., haloperidol, risperidone, thioridazine), beta-blockers (e.g., metoprolol), and Type 1C antiarrhythmics (e.g., propafenone, flecainide). Such drugs include certain antidepressants (e.g., venlafaxine, nortriptyline, imipramine, desipramine, paroxetine, fluoxetine, and sertraline), antipsychotics (e.g., haloperidol, risperidone, and thioridazine), beta-blockers...
Desipramine Also Interacts With
- Atomoxetine minor
- Darunavir minor
- Desvenlafaxine minor
- Dopamine minor
- Duloxetine minor
Bupropion Also Interacts With
- Tranylcypromine major
- Theophylline moderate
- Isavuconazonium moderate
- Metoprolol minor
- Sertraline minor
Frequently Asked Questions
What SPL severity band is on file for Desipramine + Bupropion?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Bupropion has 35 labeled pairs on file vs Desipramine's 18. In the minor band specifically: Desipramine has 18 (also Atomoxetine, Darunavir, Desvenlafaxine, Dopamine); Bupropion has 32 (also Metoprolol, Sertraline, Fluoxetine, Clopidogrel).
What mechanism field is on file for Desipramine and Bupropion?
Bupropion interferes with the way your body breaks down desipramine, causing the drug to stay in your system longer.
Bupropion carries more major-labeled pairs than Desipramine
SPL source-record counts only. This page's band is minor · classes on file: Desipramine (Tricyclic Antidepressant (TCA)); Bupropion (Norepinephrine-Dopamine Reuptake Inhibitor (NDRI)).
Bupropion has 1 major-labeled pair vs Desipramine's 0. This page itself is in the minor band, not the major band.
0 major · 0 moderate · 18 minor · 18 total
- Other minor peers for Desipramine
- Atomoxetine
- Darunavir
- Desvenlafaxine
- Dopamine
1 major · 2 moderate · 32 minor · 35 total
- Other minor peers for Bupropion
- Metoprolol
- Sertraline
- Fluoxetine
- Clopidogrel
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.