Desipramine and Darunavir Interaction
Drug interaction information between Desipramine and Darunavir.
Desipramine and Darunavir have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Desipramine and Darunavir. Major interactions are generally avoided, moderate ones may need monitoring or a dose adjustment, and minor ones are usually low-risk. This page shows the documented mechanism and guidance. Label-documented interactions are not a complete safety review, so always confirm your own medications with a pharmacist or doctor. Educational information, not medical advice.
How They Interact
Darunavir slows down the process your body uses to get rid of desipramine, leading to higher levels of the drug in your blood.
What To Do
Your doctor should use a lower dose of desipramine and watch for side effects like dizziness or fainting.
FDA Label Information
Tricyclic Antidepressants (TCAs): amitriptyline, desipramine, imipramine, nortriptyline ↑ amitriptyline ↑ desipramine ↑ imipramine ↑ nortriptyline Use a lower dose of the tricyclic antidepressants and trazodone due to potential increased adverse events such as nausea, dizziness, hypotension and syncope.
Desipramine Also Interacts With
- Atomoxetine minor
- Bupropion minor
- Desvenlafaxine minor
- Dopamine minor
- Duloxetine minor
Darunavir Also Interacts With
- Lovastatin major
- Sildenafil major
- Lurasidone major
- Pimozide major
- Midazolam major
Frequently Asked Questions
Can I take Desipramine and Darunavir together?
This is a minor interaction. Your doctor should use a lower dose of desipramine and watch for side effects like dizziness or fainting.
How serious is the interaction between Desipramine and Darunavir?
This interaction is classified as "minor" severity by the FDA. Minor interactions are unlikely to cause significant problems but should still be mentioned to your healthcare provider.
Why do Desipramine and Darunavir interact?
Darunavir slows down the process your body uses to get rid of desipramine, leading to higher levels of the drug in your blood.
Understanding the Desipramine and Darunavir Interaction
FDA-approved prescribing information for these two drugs flags their combination as a minor-severity interaction. Desipramine belongs to the Tricyclic Antidepressant (TCA) class and Darunavir belongs to the HIV Protease Inhibitor class - two categories that can collide when co-prescribed. The mechanism described in FDA labeling is: Darunavir slows down the process your body uses to get rid of desipramine, leading to higher levels of the drug in your blood. Severity tiers matter: major flags generally advise avoidance, moderate flags often require monitoring or dose adjustment, and minor flags may only call for awareness.
Context around a specific patient determines real-world impact. Desipramine has 18 total documented interactions on file in this dataset, and Darunavir has 101. Each additional medication compounds the interaction surface, which is why pharmacists run full-profile checks rather than evaluating one pair at a time. FDA-derived guidance for this pair is: Your doctor should use a lower dose of desipramine and watch for side effects like dizziness or fainting. Timing of doses, renal and hepatic function, age, and other concurrent prescriptions all shape whether a labeled interaction matters clinically.
An interaction flag is not a verdict. A large share of labeled interactions are managed routinely in clinical practice, the fix may be as simple as spacing doses or adding a monitoring test. Others require the prescriber to choose a different medication entirely. This page surfaces FDA-sourced labeling and openFDA data for educational purposes only; it is not medical advice and cannot account for your full clinical picture. Never start, stop, or adjust either Desipramine or Darunavir based on a web page, speak with your prescriber or pharmacist before making any change.
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. Always consult your healthcare provider about drug interactions.
Read our methodology - how this data is sourced, computed, and verified.