Desipramine and Darunavir Interaction
Drug interaction information between Desipramine and Darunavir.
Desipramine and Darunavir have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Desipramine and Darunavir. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Darunavir slows down the process your body uses to get rid of desipramine, leading to higher levels of the drug in your blood.
FDA Label Information
Tricyclic Antidepressants (TCAs): amitriptyline, desipramine, imipramine, nortriptyline ↑ amitriptyline ↑ desipramine ↑ imipramine ↑ nortriptyline Use a lower dose of the tricyclic antidepressants and trazodone due to potential increased adverse events such as nausea, dizziness, hypotension and syncope.
Desipramine Also Interacts With
- Atomoxetine minor
- Bupropion minor
- Desvenlafaxine minor
- Dopamine minor
- Duloxetine minor
Darunavir Also Interacts With
- Lovastatin major
- Sildenafil major
- Lurasidone major
- Pimozide major
- Midazolam major
Frequently Asked Questions
What SPL severity band is on file for Desipramine + Darunavir?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Darunavir has 101 labeled pairs on file vs Desipramine's 18. In the minor band specifically: Desipramine has 18 (also Atomoxetine, Bupropion, Desvenlafaxine, Dopamine); Darunavir has 70 (also Amlodipine, Metoprolol, Sertraline, Rosuvastatin).
What mechanism field is on file for Desipramine and Darunavir?
Darunavir slows down the process your body uses to get rid of desipramine, leading to higher levels of the drug in your blood.
Darunavir carries more major-labeled pairs than Desipramine
SPL source-record counts only. This page's band is minor · classes on file: Desipramine (Tricyclic Antidepressant (TCA)); Darunavir (HIV Protease Inhibitor).
Darunavir has 15 major-labeled pairs vs Desipramine's 0. This page itself is in the minor band, not the major band.
0 major · 0 moderate · 18 minor · 18 total
- Other minor peers for Desipramine
- Atomoxetine
- Bupropion
- Desvenlafaxine
- Dopamine
15 major · 16 moderate · 70 minor · 101 total
- Other minor peers for Darunavir
- Amlodipine
- Metoprolol
- Sertraline
- Rosuvastatin
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.