desipramine vs febuxostat
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Side-by-side comparison of desipramine and febuxostat. Data from FDA drug databases (Orange Book, NDC Directory, recalls, shortages) covering 20,000+ approved drugs, plus CMS pricing; see our methodology.
minor Known Drug Interaction
7.3 In Vivo Drug Interaction Studies Based on drug interaction studies in healthy patients, febuxostat does not have clinically significant interactions with colchicine, naproxen, indomethacin, hydrochlorothiazide, warfarin or desipramine [see Clinical Pharmacology (12.3) ].
Norpramin
Uloric
Desipramine is a medicine used to treat depression. It belongs to a class of drugs called tricyclic antidepressants.
Febuxostat (Uloric) helps manage high uric acid levels in adults with gout. It is used when allopurinol doesn't work well, causes problems, or isn't a good option.
Desipramine is used to treat depression. Depression can cause feelings of sadness, loss of interest, and trouble functioning in daily life. This medicine can help improve your mood and overall well-being.
Febuxostat treats high uric acid levels in adults who have gout. Gout is a type of arthritis that causes sudden, severe pain, swelling, and redness in your joints. This medicine is for people who can't take allopurinol, or for whom allopurinol doesn't work well enough.
Desipramine works by affecting certain chemicals in the brain. It helps to increase the levels of norepinephrine. This can improve mood and reduce symptoms of depression.
Febuxostat lowers uric acid levels in your body. It does this by blocking an enzyme called xanthine oxidase. This enzyme helps make uric acid, so blocking it reduces uric acid production.
- • Drowsiness
- • Dizziness
- • Dry mouth
- • Constipation
- • Blurred vision
- • Abnormal liver function tests
- • Nausea
- • Joint pain
- • Rash
- Fatigue 119
- Completed Suicide 116
- Nausea 77
- Headache 70
- Weight Increased 68
- Diarrhoea 849
- Nausea 841
- Acute Kidney Injury 837
- Rash 783
- Gout 686
Antidepressants may increase the risk of suicidal thoughts or actions in children, teens, and young adults. Watch for worsening depression, unusual behavior, or thoughts of suicide. Desipramine is not approved for use in children.
Febuxostat may increase the risk of death from heart problems in people with existing heart disease. Talk to your doctor about the risks and benefits of taking febuxostat. Febuxostat should only be used if allopurinol doesn't work well, causes problems, or isn't a good option for you.
Tell your doctor if you are pregnant or plan to become pregnant. Desipramine may affect your baby. Talk to your doctor about the risks and benefits of taking this medicine while pregnant or breastfeeding.
It is not known if febuxostat can harm your unborn baby. Talk to your doctor if you are pregnant or plan to become pregnant. It is also not known if febuxostat passes into breast milk. Talk to your doctor about the best way to feed your baby if you are taking this medicine.
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How to Read This desipramine vs febuxostat Comparison
desipramine is classified in the Tricyclic Antidepressant (TCA) drug class, while febuxostat sits within the Xanthine Oxidase Inhibitor class. Drugs from different classes work through distinct mechanisms, so a head-to-head comparison illustrates trade-offs rather than equivalence. Both drugs are prescription-only, so a licensed provider must authorize use.
Adverse event totals above are pulled from the FDA's Adverse Event Reporting System (FAERS). For these top-ranked reactions alone, desipramine has 450 submissions while febuxostat has 3,996. Those figures reflect cumulative reporting volume, not per-patient risk, so older, widely dispensed drugs typically look worse on count alone. These two drugs have a known minor interaction flagged in FDA labeling, attributed to these two drugs do not have a meaningful effect on how the body processes each other.. Serious warnings, pregnancy guidance, and contraindications can differ even when indications overlap.
A table cannot represent individual circumstances. Data here is sourced from FDA Structured Product Labels (SPL) and FAERS, both of which update as manufacturers and clinicians submit new information. This registry does not provide medical, treatment, substitution, or medication-change directions for desipramine or febuxostat.
Registry boundary: This comparison displays source-record fields and does not provide individualized medical direction.