Simvastatin and Dronedarone Interaction
Drug interaction information between Simvastatin and Dronedarone.
Simvastatin and Dronedarone have a documented major interaction in FDA labeling.
FDA drug labeling documents a major-severity interaction between Simvastatin and Dronedarone. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Dronedarone slows down the removal of simvastatin from your body, which can cause the drug to build up to unsafe levels. This increases the risk of serious muscle problems.
FDA Label Information
Amiodarone, Dronedarone, Ranolazine, or Calcium Channel Blockers Clinical Impact: The risk of myopathy and rhabdomyolysis is increased by concomitant use of amiodarone, dronedarone, ranolazine, or calcium channel blockers with ezetimibe and simvastatin. Intervention: For patients taking verapamil, diltiazem, or dronedarone, do not exceed ezetimibe and simvastatin 10 mg/10 mg daily.
Simvastatin Also Interacts With
- Diltiazem major
- Verapamil major
- Cyclosporine major
- Amiodarone major
- Ranolazine major
Dronedarone Also Interacts With
- Ketoconazole major
- Clarithromycin major
- Voriconazole major
- Darunavir major
- Ezetimibe major
Frequently Asked Questions
What SPL severity band is on file for Simvastatin + Dronedarone?
Compiled FDA labeling labels this pair major. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Simvastatin has 41 labeled pairs on file vs Dronedarone's 22. In the major band specifically: Simvastatin has 11 (also Diltiazem, Verapamil, Cyclosporine, Amiodarone); Dronedarone has 9 (also Ketoconazole, Clarithromycin, Voriconazole, Darunavir).
What mechanism field is on file for Simvastatin and Dronedarone?
Dronedarone slows down the removal of simvastatin from your body, which can cause the drug to build up to unsafe levels. This increases the risk of serious muscle problems.
Simvastatin carries more major-labeled pairs than Dronedarone
SPL source-record counts only. This page's band is major · classes on file: Simvastatin (HMG-CoA Reductase Inhibitor (Statin)); Dronedarone (Class III Antiarrhythmic).
Simvastatin has 11 major-labeled pairs vs Dronedarone's 9.
11 major · 9 moderate · 21 minor · 41 total
- Other major peers for Simvastatin
- Diltiazem
- Verapamil
- Cyclosporine
- Amiodarone
9 major · 5 moderate · 8 minor · 22 total
- Other major peers for Dronedarone
- Ketoconazole
- Clarithromycin
- Voriconazole
- Darunavir
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.