Simvastatin and Colchicine Interaction
Drug interaction information between Simvastatin and Colchicine.
Simvastatin and Colchicine have a documented moderate interaction in FDA labeling.
FDA drug labeling documents a moderate-severity interaction between Simvastatin and Colchicine. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Using these two medicines at the same time can lead to muscle pain and serious muscle damage.
FDA Label Information
Colchicine Clinical Impact: Cases of myopathy and rhabdomyolysis have been reported with concomitant use of colchicine with ezetimibe and simvastatin. Intervention: Consider if the benefit of using colchicine concomitantly with ezetimibe and simvastatin outweighs the increased risk of myopathy and rhabdomyolysis.
Simvastatin Also Interacts With
- Diltiazem major
- Verapamil major
- Cyclosporine major
- Amiodarone major
- Dronedarone major
Colchicine Also Interacts With
- Clarithromycin major
- Darunavir major
- Itraconazole major
- Nirmatrelvir/Ritonavir major
- Atorvastatin moderate
Frequently Asked Questions
What SPL severity band is on file for Simvastatin + Colchicine?
Compiled FDA labeling labels this pair moderate. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Simvastatin has 41 labeled pairs on file vs Colchicine's 28. In the moderate band specifically: Simvastatin has 9 (also Ezetimibe, Daptomycin, Niacin, Bempedoic Acid); Colchicine has 9 (also Atorvastatin, Ezetimibe, Ezetimibe/Simvastatin, Fenofibrate).
What mechanism field is on file for Simvastatin and Colchicine?
Using these two medicines at the same time can lead to muscle pain and serious muscle damage.
Simvastatin carries more major-labeled pairs than Colchicine
SPL source-record counts only. This page's band is moderate · classes on file: Simvastatin (HMG-CoA Reductase Inhibitor (Statin)); Colchicine (Anti-Gout Agent).
Simvastatin has 11 major-labeled pairs vs Colchicine's 4. This page itself is in the moderate band, not the major band.
11 major · 9 moderate · 21 minor · 41 total
- Other moderate peers for Simvastatin
- Ezetimibe
- Daptomycin
- Niacin
- Bempedoic Acid
4 major · 9 moderate · 15 minor · 28 total
- Other moderate peers for Colchicine
- Atorvastatin
- Ezetimibe
- Ezetimibe/Simvastatin
- Fenofibrate
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.