Simvastatin and Ezetimibe Interaction
Drug interaction information between Simvastatin and Ezetimibe.
Simvastatin and Ezetimibe have a documented moderate interaction in FDA labeling.
FDA drug labeling documents a moderate-severity interaction between Simvastatin and Ezetimibe. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Using these two cholesterol medicines together can increase the risk of muscle damage or weakness. This happens because both drugs can affect your muscles in similar ways.
FDA Label Information
7 DRUG INTERACTIONS Ezetimibe and S imvastatin See full prescribing information for details regarding concomitant use of ezetimibe and simvastatin tablets with other drugs or grapefruit juice that increase the risk of myopathy and rhabdomyolysis. ( 2.3 , 7.1 ) Cholestyramine : Combination decreases exposure of ezetimibe. ( 2.3 , 7.2 ) Coumarin Anticoagulants: Obtain INR before ezetimibe and simvastatin tablets initiation and monitor INR during ezetimibe and simvastatin tablets dosage initiation or adjustment.
Simvastatin Also Interacts With
- Diltiazem major
- Verapamil major
- Cyclosporine major
- Amiodarone major
- Dronedarone major
Ezetimibe Also Interacts With
- Amlodipine major
- Diltiazem major
- Verapamil major
- Cyclosporine major
- Amiodarone major
Frequently Asked Questions
What SPL severity band is on file for Simvastatin + Ezetimibe?
Compiled FDA labeling labels this pair moderate. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Simvastatin has 41 labeled pairs on file vs Ezetimibe's 25. In the moderate band specifically: Simvastatin has 9 (also Daptomycin, Colchicine, Niacin, Bempedoic Acid); Ezetimibe has 4 (also Daptomycin, Colchicine, Niacin).
What mechanism field is on file for Simvastatin and Ezetimibe?
Using these two cholesterol medicines together can increase the risk of muscle damage or weakness. This happens because both drugs can affect your muscles in similar ways.
Simvastatin carries more major-labeled pairs than Ezetimibe
SPL source-record counts only. This page's band is moderate · classes on file: Simvastatin (HMG-CoA Reductase Inhibitor (Statin)); Ezetimibe (Cholesterol Absorption Inhibitor).
Simvastatin has 11 major-labeled pairs vs Ezetimibe's 8. This page itself is in the moderate band, not the major band.
11 major · 9 moderate · 21 minor · 41 total
- Other moderate peers for Simvastatin
- Daptomycin
- Colchicine
- Niacin
- Bempedoic Acid
8 major · 4 moderate · 13 minor · 25 total
- Other moderate peers for Ezetimibe
- Daptomycin
- Colchicine
- Niacin
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.