Simvastatin and Amiodarone Interaction
Drug interaction information between Simvastatin and Amiodarone.
Simvastatin and Amiodarone have a documented major interaction in FDA labeling.
FDA drug labeling documents a major-severity interaction between Simvastatin and Amiodarone. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Amiodarone interferes with how your body breaks down simvastatin, leading to higher levels of the medicine in your blood. This makes muscle damage more likely to happen.
FDA Label Information
Amiodarone, Dronedarone, Ranolazine, or Calcium Channel Blockers Clinical Impact: The risk of myopathy and rhabdomyolysis is increased by concomitant use of amiodarone, dronedarone, ranolazine, or calcium channel blockers with ezetimibe and simvastatin. For patients taking amiodarone, amlodipine, or ranolazine, do not exceed ezetimibe and simvastatin 10 mg/20 mg daily [see Dosage and Administration ( 2.3 )].
Simvastatin Also Interacts With
- Diltiazem major
- Verapamil major
- Cyclosporine major
- Dronedarone major
- Ranolazine major
Amiodarone Also Interacts With
- Ezetimibe major
- Ezetimibe/Simvastatin major
- Nirmatrelvir/Ritonavir major
- Lithium moderate
- Clarithromycin moderate
Frequently Asked Questions
What SPL severity band is on file for Simvastatin + Amiodarone?
Compiled FDA labeling labels this pair major. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Amiodarone has 42 labeled pairs on file vs Simvastatin's 41. In the major band specifically: Simvastatin has 11 (also Diltiazem, Verapamil, Cyclosporine, Dronedarone); Amiodarone has 4 (also Ezetimibe, Ezetimibe/Simvastatin, Nirmatrelvir/Ritonavir).
What mechanism field is on file for Simvastatin and Amiodarone?
Amiodarone interferes with how your body breaks down simvastatin, leading to higher levels of the medicine in your blood. This makes muscle damage more likely to happen.
Simvastatin carries more major-labeled pairs than Amiodarone
SPL source-record counts only. This page's band is major · classes on file: Simvastatin (HMG-CoA Reductase Inhibitor (Statin)); Amiodarone (Class III Antiarrhythmic).
Simvastatin has 11 major-labeled pairs vs Amiodarone's 4.
11 major · 9 moderate · 21 minor · 41 total
- Other major peers for Simvastatin
- Diltiazem
- Verapamil
- Cyclosporine
- Dronedarone
4 major · 9 moderate · 29 minor · 42 total
- Other major peers for Amiodarone
- Ezetimibe
- Ezetimibe/Simvastatin
- Nirmatrelvir/Ritonavir
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.