Simvastatin and Verapamil Interaction
Drug interaction information between Simvastatin and Verapamil.
Simvastatin and Verapamil have a documented major interaction in FDA labeling.
FDA drug labeling documents a major-severity interaction between Simvastatin and Verapamil. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Verapamil slows down the process your body uses to get rid of simvastatin, which can cause the drug to reach toxic levels. This increases the risk of serious muscle injury.
FDA Label Information
Intervention: For patients taking verapamil, diltiazem, or dronedarone, do not exceed ezetimibe and simvastatin 10 mg/10 mg daily.
Simvastatin Also Interacts With
- Diltiazem major
- Cyclosporine major
- Amiodarone major
- Dronedarone major
- Ranolazine major
Verapamil Also Interacts With
- Eplerenone major
- Ezetimibe major
- Ezetimibe/Simvastatin major
- Clarithromycin moderate
- Lovastatin moderate
Frequently Asked Questions
What SPL severity band is on file for Simvastatin + Verapamil?
Compiled FDA labeling labels this pair major. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Verapamil has 57 labeled pairs on file vs Simvastatin's 41. In the major band specifically: Simvastatin has 11 (also Diltiazem, Cyclosporine, Amiodarone, Dronedarone); Verapamil has 4 (also Eplerenone, Ezetimibe, Ezetimibe/Simvastatin).
What mechanism field is on file for Simvastatin and Verapamil?
Verapamil slows down the process your body uses to get rid of simvastatin, which can cause the drug to reach toxic levels. This increases the risk of serious muscle injury.
Simvastatin carries more major-labeled pairs than Verapamil
SPL source-record counts only. This page's band is major · classes on file: Simvastatin (HMG-CoA Reductase Inhibitor (Statin)); Verapamil (Calcium Channel Blocker).
Simvastatin has 11 major-labeled pairs vs Verapamil's 4.
11 major · 9 moderate · 21 minor · 41 total
- Other major peers for Simvastatin
- Diltiazem
- Cyclosporine
- Amiodarone
- Dronedarone
4 major · 6 moderate · 47 minor · 57 total
- Other major peers for Verapamil
- Eplerenone
- Ezetimibe
- Ezetimibe/Simvastatin
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.